Abstract
Objective Because of the relevance for the research on
sleep deprivation and human behaviour, many preclinical
studies have been conducted on aggressive, sexual and
maternal behaviours in this field. Considering the available
data and the complexity of the factors involved, the
most appropriate way to summarise the effects of sleep
deprivation on these behaviours is through systematic
reviews and meta-analyses. This article describes the
protocol for three independent systematic reviews and
meta-analyses, evaluating the effects of sleep deprivation
on aggressive, sexual and maternal behaviours in animals.
earch strategy A bibliographic search will be performed
in four databases: Pubmed, Scopus, Web of Science and
Psychinfo, searching for three domains: sleep deprivation
(as the intervention), animals (as the population) and
behaviour (as the outcome).
creening and annotation Titles and abstracts will first
be screened, followed by analysis of the full text and data
extraction.
Data management and reporting SYstematic Review
Centre for Laboratory Animal Experimentation ’s risk
of bias tool will be used to evaluate risk of bias; visual
analysis of funnel plots, Egger’s regression and trim-andfill will be employed to evaluate publication bias. Effect
sizes will be calculated from the articles by either direct or
standardised mean difference, depending on the nature of
the data. Overall estimates will then be calculated using
a random effects model. Heterogeneity will be assessed
using both I2
index and Cochran’s Q test. These metaanalyses should be useful to summarise the available
data on the relationship between sleep deprivation
and behaviour, providing a solid background for future
behavioural sleep deprivation experiments, improving their
validity.
sleep deprivation and human behaviour, many preclinical
studies have been conducted on aggressive, sexual and
maternal behaviours in this field. Considering the available
data and the complexity of the factors involved, the
most appropriate way to summarise the effects of sleep
deprivation on these behaviours is through systematic
reviews and meta-analyses. This article describes the
protocol for three independent systematic reviews and
meta-analyses, evaluating the effects of sleep deprivation
on aggressive, sexual and maternal behaviours in animals.
earch strategy A bibliographic search will be performed
in four databases: Pubmed, Scopus, Web of Science and
Psychinfo, searching for three domains: sleep deprivation
(as the intervention), animals (as the population) and
behaviour (as the outcome).
creening and annotation Titles and abstracts will first
be screened, followed by analysis of the full text and data
extraction.
Data management and reporting SYstematic Review
Centre for Laboratory Animal Experimentation ’s risk
of bias tool will be used to evaluate risk of bias; visual
analysis of funnel plots, Egger’s regression and trim-andfill will be employed to evaluate publication bias. Effect
sizes will be calculated from the articles by either direct or
standardised mean difference, depending on the nature of
the data. Overall estimates will then be calculated using
a random effects model. Heterogeneity will be assessed
using both I2
index and Cochran’s Q test. These metaanalyses should be useful to summarise the available
data on the relationship between sleep deprivation
and behaviour, providing a solid background for future
behavioural sleep deprivation experiments, improving their
validity.
| Original language | English |
|---|---|
| Article number | e000041 |
| Journal | Open Computer Science |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Nov 2018 |
| Externally published | Yes |