TY - JOUR
T1 - Effects of early life stress on rodent hippocampal synaptic plasticity
T2 - a systematic review
AU - Derks, Nienke AV
AU - Krugers, Harm J
AU - Hoogenraad, Casper C.
AU - Joëls, Marian
AU - Sarabdjitsingh, R.A.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Early life stress shapes brain development and animal behavior. Neurophysiological properties such as signal transmission and synaptic plasticity are thought to underlie the animal's behavioral performance. We carried out a systematic review to determine how early life stress relates to neurophysiology in rodents. We specifically discuss effects on basal transmission and long-term potentiation in the hippocampus, as this brain area undergoes strong developmental changes during the first postnatal weeks. In general, basal transmission does not appear to be affected by early life conditions. Long-term potentiation is mainly increased by mild stress, while it is impaired by more severe early life stressors. The dentate gyrus shows stronger effects than the CA1 area. These changes may impact on hippocampus-dependent behavior. We conclude that rodent early life stress models provide important insights in stressor-dependent effects after human childhood adversity.
AB - Early life stress shapes brain development and animal behavior. Neurophysiological properties such as signal transmission and synaptic plasticity are thought to underlie the animal's behavioral performance. We carried out a systematic review to determine how early life stress relates to neurophysiology in rodents. We specifically discuss effects on basal transmission and long-term potentiation in the hippocampus, as this brain area undergoes strong developmental changes during the first postnatal weeks. In general, basal transmission does not appear to be affected by early life conditions. Long-term potentiation is mainly increased by mild stress, while it is impaired by more severe early life stressors. The dentate gyrus shows stronger effects than the CA1 area. These changes may impact on hippocampus-dependent behavior. We conclude that rodent early life stress models provide important insights in stressor-dependent effects after human childhood adversity.
UR - http://www.scopus.com/inward/record.url?scp=85017288022&partnerID=8YFLogxK
U2 - 10.1016/j.cobeha.2017.03.005
DO - 10.1016/j.cobeha.2017.03.005
M3 - Review article
AN - SCOPUS:85017288022
SN - 2352-1546
VL - 14
SP - 155
EP - 166
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
ER -