Abstract
Respiratory autonomic β-adrenergic receptor function was investigated in isolated tracheal spirals of guinea pigs receiving different diets. Comparison was made between control and Haemophilus influenzae treated animals; this latter group serving as animal model for atopy. The different semi-synthetic diets (35 energy%) varying in their linoleic acid contents (5.85, 11.25 and 22.05 en%), exerted profound effects on membrane fatty acid composition. No influence of these diets on either food intake or growth could be detected. Isoprenaline indcued relaxation of guinea pig tracheal spirals was maximal in the dietary group receiving moderate linoleic acid (11.25 en%). Both the addition and the withdrawal of linoleic acid to this diet resulted in a significant impairment of β-adrenergic receptor function, to the same extent as can be induced by Haemophilus influenzae. The results are discussed in view of current concepts for atopy.
| Original language | English |
|---|---|
| Pages (from-to) | 127-134 |
| Number of pages | 8 |
| Journal | Prostaglandins, Leukotrienes and Essential Fatty Acids |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 28 Mar 1988 |
Keywords
- beta adrenergic receptor
- isoprenaline
- linoleic acid
- animal cell
- controlled study
- diet
- drug receptor binding
- guinea pig
- Haemophilus influenzae
- lung alveolus membrane
- male
- nonhuman
- priority journal
- trachea muscle