TY - JOUR
T1 - Effects of body mass on microstructural features of the osteochondral unit
T2 - A comparative analysis of 37 mammalian species
AU - Mancini, I.A.D.
AU - Rieppo, L.
AU - Pouran, B.
AU - Afara, I.O.
AU - Braganca, F.M. Serra
AU - van Rijen, M.H.P.
AU - Kik, M.
AU - Weinans, H.
AU - Toyras, J.
AU - van Weeren, P.R.
AU - Malda, J.
PY - 2019/7
Y1 - 2019/7
N2 - Since Galileo's days the effect of size on the anatomical characteristics of the structural elements of the body has been a subject of interest. However, the effects of scaling at tissue level have received little interest and virtually no data exist on the subject with respect to the osteochondral unit in the joint, despite this being one of the most lesion-prone and clinically relevant parts of the musculoskeletal system. Imaging techniques, including FTIR imaging, polarized light microscopy and micro computed tomography, were combined to study the response to increasing body mass of the osteochondral unit. We analyzed the effect of scaling on structural characteristics of articular cartilage, subchondral plate and the supporting trabecular bone, across a wide range of mammals at microscopic level. We demonstrated that, while total cartilage thickness scales to body mass in a negative allometric fashion, thickness of different cartilage layers did not. Cartilage tissue layers were found to adapt to increasing loads principally in the deep zone with the superficial layers becoming relatively thinner. While subchondral plate thickness was found to have no correlation to body mass, bone volume fraction correlated negatively to body mass (r = -0.41, p
AB - Since Galileo's days the effect of size on the anatomical characteristics of the structural elements of the body has been a subject of interest. However, the effects of scaling at tissue level have received little interest and virtually no data exist on the subject with respect to the osteochondral unit in the joint, despite this being one of the most lesion-prone and clinically relevant parts of the musculoskeletal system. Imaging techniques, including FTIR imaging, polarized light microscopy and micro computed tomography, were combined to study the response to increasing body mass of the osteochondral unit. We analyzed the effect of scaling on structural characteristics of articular cartilage, subchondral plate and the supporting trabecular bone, across a wide range of mammals at microscopic level. We demonstrated that, while total cartilage thickness scales to body mass in a negative allometric fashion, thickness of different cartilage layers did not. Cartilage tissue layers were found to adapt to increasing loads principally in the deep zone with the superficial layers becoming relatively thinner. While subchondral plate thickness was found to have no correlation to body mass, bone volume fraction correlated negatively to body mass (r = -0.41, p
KW - osteochondral unit
KW - trabecular bone
KW - subchondral bone
KW - carilage
KW - osteochondral comparative analysis
KW - scaling
U2 - 10.1016/j.bone.2019.07.001
DO - 10.1016/j.bone.2019.07.001
M3 - Article
C2 - 31279095
SN - 8756-3282
VL - 127
SP - 664
EP - 673
JO - Bone
JF - Bone
ER -