Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Infl uenza A (H7N7) Epidemic, the Netherlands, 2003

D.E. te Beest; M. van Boven; M.E.H. Bos; A. Stegeman; M.P.G. Koopmans

doi:10.3201/eid1610.091412

Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Infl uenza A (H7N7) Epidemic, the Netherlands, 2003

D.E. te Beest, M. van Boven, M.E.H. Bos, A. Stegeman, M.P.G. Koopmans

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We analyzed the effectiveness of personal protective
equipment and oseltamivir use during the 2003 avian in-
fluenza A (H7N7) epidemic in the Netherlands by linking
databases containing information about farm visits, human
infections, and use of oseltamivir and personal protective
equipment. Using a stringent case de finition, based on
self-reported conjunctivitis combined with a positive he-
magglutination-inhibition assay, we found that prophylactic
treatment with oseltamivir significantly reduced the risk for
infection per farm visit from 0.145 (95% con fidence inter-
val [CI] 0.078–0.233) to 0.031 (95% CI 0.008–0.073). The
protective effect was ≈79% (95% CI 40%–97%). These
results are comparable with the reported effect of prophy-
lactic treatment with oseltamivir on human seasonal in flu-
enza. No significant protective effect was found for use of
respirators or safety glasses, possibly because of limita-
tions of the data

Original language	English
Pages (from-to)	1562-1568
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	16
Issue number	10
DOIs	https://doi.org/10.3201/eid1610.091412
Publication status	Published - 2010

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title = "Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Infl uenza A (H7N7) Epidemic, the Netherlands, 2003",

abstract = "We analyzed the effectiveness of personal protectiveequipment and oseltamivir use during the 2003 avian in-fluenza A (H7N7) epidemic in the Netherlands by linkingdatabases containing information about farm visits, humaninfections, and use of oseltamivir and personal protectiveequipment. Using a stringent case de finition, based onself-reported conjunctivitis combined with a positive he-magglutination-inhibition assay, we found that prophylactictreatment with oseltamivir significantly reduced the risk forinfection per farm visit from 0.145 (95% con fidence inter-val [CI] 0.078–0.233) to 0.031 (95% CI 0.008–0.073). Theprotective effect was ≈79% (95% CI 40%–97%). Theseresults are comparable with the reported effect of prophy-lactic treatment with oseltamivir on human seasonal in flu-enza. No significant protective effect was found for use ofrespirators or safety glasses, possibly because of limita-tions of the data",

author = "{te Beest}, D.E. and {van Boven}, M. and M.E.H. Bos and A. Stegeman and M.P.G. Koopmans",

year = "2010",

doi = "10.3201/eid1610.091412",

language = "English",

volume = "16",

pages = "1562--1568",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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T1 - Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Infl uenza A (H7N7) Epidemic, the Netherlands, 2003

AU - te Beest, D.E.

AU - van Boven, M.

AU - Bos, M.E.H.

AU - Stegeman, A.

AU - Koopmans, M.P.G.

PY - 2010

Y1 - 2010

N2 - We analyzed the effectiveness of personal protectiveequipment and oseltamivir use during the 2003 avian in-fluenza A (H7N7) epidemic in the Netherlands by linkingdatabases containing information about farm visits, humaninfections, and use of oseltamivir and personal protectiveequipment. Using a stringent case de finition, based onself-reported conjunctivitis combined with a positive he-magglutination-inhibition assay, we found that prophylactictreatment with oseltamivir significantly reduced the risk forinfection per farm visit from 0.145 (95% con fidence inter-val [CI] 0.078–0.233) to 0.031 (95% CI 0.008–0.073). Theprotective effect was ≈79% (95% CI 40%–97%). Theseresults are comparable with the reported effect of prophy-lactic treatment with oseltamivir on human seasonal in flu-enza. No significant protective effect was found for use ofrespirators or safety glasses, possibly because of limita-tions of the data

AB - We analyzed the effectiveness of personal protectiveequipment and oseltamivir use during the 2003 avian in-fluenza A (H7N7) epidemic in the Netherlands by linkingdatabases containing information about farm visits, humaninfections, and use of oseltamivir and personal protectiveequipment. Using a stringent case de finition, based onself-reported conjunctivitis combined with a positive he-magglutination-inhibition assay, we found that prophylactictreatment with oseltamivir significantly reduced the risk forinfection per farm visit from 0.145 (95% con fidence inter-val [CI] 0.078–0.233) to 0.031 (95% CI 0.008–0.073). Theprotective effect was ≈79% (95% CI 40%–97%). Theseresults are comparable with the reported effect of prophy-lactic treatment with oseltamivir on human seasonal in flu-enza. No significant protective effect was found for use ofrespirators or safety glasses, possibly because of limita-tions of the data

U2 - 10.3201/eid1610.091412

DO - 10.3201/eid1610.091412

M3 - Article

SN - 1080-6040

VL - 16

SP - 1562

EP - 1568

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 10

ER -

Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Infl uenza A (H7N7) Epidemic, the Netherlands, 2003

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