Effect of drugs on renal development

Michiel F Schreuder, Ruud R Bueters, Marleen C Huigen, Frans G M Russel, R. Masereeuw, Lambertus P van den Heuvel

Research output: Contribution to journalReview articlepeer-review

Abstract

Many nephrotoxic effects of drugs have been described, whereas the effect on renal development has received less attention. Nephrogenesis ceases at approximately 36 weeks of gestation, indicating that drugs administered to pregnant women and to preterm-born neonates may influence kidney development. Such an effect on renal development may lead to a wide spectrum of renal malformations (congenital anomalies of the kidney and urinary tract [CAKUT]), ranging from renal agenesis to a reduced nephron number. Any of these anomalies may have long-term sequelae, and CAKUT is the primary cause for renal replacement therapy in childhood. This review focuses on research into the effect of drug treatment during active nephrogenesis during pregnancy and in preterm-born infants. Because the effects of many widely used drugs have not been unraveled thus far, more research is needed to study the effect on renal development and long-term renal sequelae after drug treatment during nephrogenesis.

Original languageEnglish
Pages (from-to)212-7
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Animals
  • Female
  • Humans
  • Kidney
  • Pregnancy
  • Renin-Angiotensin System
  • Urinary Tract

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