TY - JOUR
T1 - Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study
AU - Tischer, Christina
AU - Casas, Lidia
AU - Wouters, Inge M
AU - Doekes, Gert
AU - Garcia-Esteban, Raquel
AU - Gehring, Ulrike
AU - Hyvärinen, Anne
AU - Oldenwening, Marieke
AU - Kerkhof, Marjan
AU - Sunyer, Jordi
AU - Standl, Marie
AU - Thiering, Elisabeth
AU - Torrent, Maties
AU - Heinrich, Joachim
AU - the HITEA study group
N1 - ©ERS.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n = 553; INMA: n = 481; and LISAplus: n = 395), endotoxin, (1,3,)-β-d-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3)-β-d-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments.
AB - Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n = 553; INMA: n = 481; and LISAplus: n = 395), endotoxin, (1,3,)-β-d-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3)-β-d-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments.
U2 - 10.1183/09031936.00060214
DO - 10.1183/09031936.00060214
M3 - Article
C2 - 25186271
SN - 0903-1936
VL - 45
SP - 328
EP - 337
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 2
ER -