Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

E.J. Koers; M.P. López-Deber; M.H. Weingarth; D. Nand; D.T. Hickman; D. Mlaki Ndao; P. Reis; A. Granet; A. Pfeifer; A. Muhs; M. Baldus

doi:10.1002/anie.201303374

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

E.J. Koers, M.P. López-Deber, M.H. Weingarth, D. Nand, D.T. Hickman, D. Mlaki Ndao, P. Reis, A. Granet, A. Pfeifer, A. Muhs, M. Baldus

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.

Original language	English
Pages (from-to)	10905-10908
Number of pages	4
Journal	Angewandte Chemie-International Edition
Volume	52
Issue number	41
DOIs	https://doi.org/10.1002/anie.201303374
Publication status	Published - 2013

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Koers, E. J., López-Deber, M. P., Weingarth, M. H., Nand, D., Hickman, D. T., Mlaki Ndao, D., Reis, P., Granet, A., Pfeifer, A., Muhs, A., & Baldus, M. (2013). Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines. Angewandte Chemie-International Edition, 52(41), 10905-10908. https://doi.org/10.1002/anie.201303374

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abstract = "Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.",

author = "E.J. Koers and M.P. L{\'o}pez-Deber and M.H. Weingarth and D. Nand and D.T. Hickman and {Mlaki Ndao}, D. and P. Reis and A. Granet and A. Pfeifer and A. Muhs and M. Baldus",

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Koers, EJ, López-Deber, MP, Weingarth, MH, Nand, D, Hickman, DT, Mlaki Ndao, D, Reis, P, Granet, A, Pfeifer, A, Muhs, A & Baldus, M 2013, 'Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines', Angewandte Chemie-International Edition, vol. 52, no. 41, pp. 10905-10908. https://doi.org/10.1002/anie.201303374

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T1 - Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

AU - Koers, E.J.

AU - López-Deber, M.P.

AU - Weingarth, M.H.

AU - Nand, D.

AU - Hickman, D.T.

AU - Mlaki Ndao, D.

AU - Reis, P.

AU - Granet, A.

AU - Pfeifer, A.

AU - Muhs, A.

AU - Baldus, M.

PY - 2013

Y1 - 2013

N2 - Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.

AB - Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.

U2 - 10.1002/anie.201303374

DO - 10.1002/anie.201303374

M3 - Article

SN - 1433-7851

VL - 52

SP - 10905

EP - 10908

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

IS - 41

ER -

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

Abstract

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