Drug-induced sexual dysfunction in rats.

J.S.W. Chan, M.D. Waldinger, B. Olivier, R.S. Oosting

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This unit describes the testing of sexual behaviors of male Wistar rats. The described test enables the detection of stimulatory and inhibitory profiles of compounds. The test includes four training sessions to reach a stable sexual performance, followed by acute and/or chronic administration of drugs. The main quantifiable sexual behaviors are number of mounts (no vaginal penetration), intromissions (vaginal penetration), and ejaculations. By comparing the test compound to reference compound(s), sexual (side) effects can be determined.
Original languageUndefined/Unknown
Number of pages1
JournalCurr Protoc Neurosci
VolumeChapter 9
Publication statusPublished - 2010

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