DOUBLE-BLIND STUDY OF LEUCOCYTE INTERFERON ADMINISTRATION IN CHRONIC HBsAg-POSITIVE HEPATITIS

W. Weimar; F. J.P. Ten Kate; N. Masurel; R. A. Heijtink; S. W. Schalm; H. Schellekens; K. Cantell

doi:10.1016/S0140-6736(80)90885-5

DOUBLE-BLIND STUDY OF LEUCOCYTE INTERFERON ADMINISTRATION IN CHRONIC HBsAg-POSITIVE HEPATITIS

W. Weimar^*
, F. J.P. Ten Kate
, N. Masurel
, R. A. Heijtink
, S. W. Schalm
, H. Schellekens
, K. Cantell

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12×10⁶ reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.

Original language	English
Pages (from-to)	336-338
Number of pages	3
Journal	The Lancet
Volume	315
Issue number	8164
DOIs	https://doi.org/10.1016/S0140-6736(80)90885-5
Publication status	Published - 16 Feb 1980
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/S0140-6736(80)90885-5

Cite this

@article{85b33752996144988d85ddd21481e4fb,

title = "DOUBLE-BLIND STUDY OF LEUCOCYTE INTERFERON ADMINISTRATION IN CHRONIC HBsAg-POSITIVE HEPATITIS",

abstract = "In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12×106 reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.",

author = "W. Weimar and \{Ten Kate\}, \{F. J.P.\} and N. Masurel and Heijtink, \{R. A.\} and Schalm, \{S. W.\} and H. Schellekens and K. Cantell",

year = "1980",

month = feb,

day = "16",

doi = "10.1016/S0140-6736(80)90885-5",

language = "English",

volume = "315",

pages = "336--338",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier BV",

number = "8164",

}

TY - JOUR

T1 - DOUBLE-BLIND STUDY OF LEUCOCYTE INTERFERON ADMINISTRATION IN CHRONIC HBsAg-POSITIVE HEPATITIS

AU - Weimar, W.

AU - Ten Kate, F. J.P.

AU - Masurel, N.

AU - Heijtink, R. A.

AU - Schalm, S. W.

AU - Schellekens, H.

AU - Cantell, K.

PY - 1980/2/16

Y1 - 1980/2/16

N2 - In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12×106 reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.

AB - In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12×106 reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.

UR - https://www.scopus.com/pages/publications/0018913696

U2 - 10.1016/S0140-6736(80)90885-5

DO - 10.1016/S0140-6736(80)90885-5

M3 - Article

C2 - 6101791

AN - SCOPUS:0018913696

SN - 0140-6736

VL - 315

SP - 336

EP - 338

JO - The Lancet

JF - The Lancet

IS - 8164

ER -

DOUBLE-BLIND STUDY OF LEUCOCYTE INTERFERON ADMINISTRATION IN CHRONIC HBsAg-POSITIVE HEPATITIS

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this