Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats

Marcia Spoelder; Annemarie M Baars; Marthe D Rotte; Louk J M J Vanderschuren; Heidi M B Lesscher

doi:10.1007/s00213-016-4330-x

Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats

Marcia Spoelder, Annemarie M Baars, Marthe D Rotte, Louk J M J Vanderschuren, Heidi M B Lesscher

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

RATIONALE: Individual susceptibility to alcohol use disorder has been related to functional changes in dopaminergic neurotransmission.

OBJECTIVES: The aim of the current work was to assess the effects of selective dopamine D1 and D2 receptor agonists and antagonists on alcohol consumption in rats that differ in individual levels of alcohol intake.

METHODS: The effects of the dopamine D1 receptor agonist SKF 82958, the dopamine D1 receptor antagonist SCH 23390, the dopamine D2 receptor agonist sumanirole and the dopamine D2 receptor antagonist L741,626 on alcohol consumption and preference were assessed at different time points after treatment in subgroups of low and high alcohol drinking rats (LD and HD) using an intermittent alcohol access paradigm.

RESULTS: SKF 82958 decreased alcohol intake and alcohol preference throughout the 24-h session. Sumanirole decreased alcohol intake during the first 2 h, but increased alcohol intake during the remainder of the session. The effects of SKF 82958 and sumanirole on alcohol intake and alcohol preference were comparable in LD and HD. By contrast, the dopamine receptor antagonists SCH 23390 and L741,626 did not alter alcohol consumption in either group at any time point.

CONCLUSIONS: These data indicate that stimulation of dopamine D1 receptors reduces alcohol intake, but that endogenous dopamine does not play a primary role in alcohol consumption. Moreover, the difference in alcohol consumption between LD and HD does not involve altered dopamine signaling.

Original language	English
Pages (from-to)	2715–2725
Number of pages	11
Journal	Psychopharmacology
Volume	233
Issue number	14
DOIs	https://doi.org/10.1007/s00213-016-4330-x
Publication status	Published - 2016

Keywords

Addiction
Alcohol
Dopamine receptor
Individual differences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats",

abstract = "RATIONALE: Individual susceptibility to alcohol use disorder has been related to functional changes in dopaminergic neurotransmission.OBJECTIVES: The aim of the current work was to assess the effects of selective dopamine D1 and D2 receptor agonists and antagonists on alcohol consumption in rats that differ in individual levels of alcohol intake.METHODS: The effects of the dopamine D1 receptor agonist SKF 82958, the dopamine D1 receptor antagonist SCH 23390, the dopamine D2 receptor agonist sumanirole and the dopamine D2 receptor antagonist L741,626 on alcohol consumption and preference were assessed at different time points after treatment in subgroups of low and high alcohol drinking rats (LD and HD) using an intermittent alcohol access paradigm.RESULTS: SKF 82958 decreased alcohol intake and alcohol preference throughout the 24-h session. Sumanirole decreased alcohol intake during the first 2 h, but increased alcohol intake during the remainder of the session. The effects of SKF 82958 and sumanirole on alcohol intake and alcohol preference were comparable in LD and HD. By contrast, the dopamine receptor antagonists SCH 23390 and L741,626 did not alter alcohol consumption in either group at any time point.CONCLUSIONS: These data indicate that stimulation of dopamine D1 receptors reduces alcohol intake, but that endogenous dopamine does not play a primary role in alcohol consumption. Moreover, the difference in alcohol consumption between LD and HD does not involve altered dopamine signaling.",

keywords = "Addiction, Alcohol, Dopamine receptor, Individual differences",

author = "Marcia Spoelder and Baars, {Annemarie M} and Rotte, {Marthe D} and Vanderschuren, {Louk J M J} and Lesscher, {Heidi M B}",

year = "2016",

doi = "10.1007/s00213-016-4330-x",

language = "English",

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journal = "Psychopharmacology",

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TY - JOUR

T1 - Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats

AU - Spoelder, Marcia

AU - Baars, Annemarie M

AU - Rotte, Marthe D

AU - Vanderschuren, Louk J M J

AU - Lesscher, Heidi M B

PY - 2016

Y1 - 2016

N2 - RATIONALE: Individual susceptibility to alcohol use disorder has been related to functional changes in dopaminergic neurotransmission.OBJECTIVES: The aim of the current work was to assess the effects of selective dopamine D1 and D2 receptor agonists and antagonists on alcohol consumption in rats that differ in individual levels of alcohol intake.METHODS: The effects of the dopamine D1 receptor agonist SKF 82958, the dopamine D1 receptor antagonist SCH 23390, the dopamine D2 receptor agonist sumanirole and the dopamine D2 receptor antagonist L741,626 on alcohol consumption and preference were assessed at different time points after treatment in subgroups of low and high alcohol drinking rats (LD and HD) using an intermittent alcohol access paradigm.RESULTS: SKF 82958 decreased alcohol intake and alcohol preference throughout the 24-h session. Sumanirole decreased alcohol intake during the first 2 h, but increased alcohol intake during the remainder of the session. The effects of SKF 82958 and sumanirole on alcohol intake and alcohol preference were comparable in LD and HD. By contrast, the dopamine receptor antagonists SCH 23390 and L741,626 did not alter alcohol consumption in either group at any time point.CONCLUSIONS: These data indicate that stimulation of dopamine D1 receptors reduces alcohol intake, but that endogenous dopamine does not play a primary role in alcohol consumption. Moreover, the difference in alcohol consumption between LD and HD does not involve altered dopamine signaling.

AB - RATIONALE: Individual susceptibility to alcohol use disorder has been related to functional changes in dopaminergic neurotransmission.OBJECTIVES: The aim of the current work was to assess the effects of selective dopamine D1 and D2 receptor agonists and antagonists on alcohol consumption in rats that differ in individual levels of alcohol intake.METHODS: The effects of the dopamine D1 receptor agonist SKF 82958, the dopamine D1 receptor antagonist SCH 23390, the dopamine D2 receptor agonist sumanirole and the dopamine D2 receptor antagonist L741,626 on alcohol consumption and preference were assessed at different time points after treatment in subgroups of low and high alcohol drinking rats (LD and HD) using an intermittent alcohol access paradigm.RESULTS: SKF 82958 decreased alcohol intake and alcohol preference throughout the 24-h session. Sumanirole decreased alcohol intake during the first 2 h, but increased alcohol intake during the remainder of the session. The effects of SKF 82958 and sumanirole on alcohol intake and alcohol preference were comparable in LD and HD. By contrast, the dopamine receptor antagonists SCH 23390 and L741,626 did not alter alcohol consumption in either group at any time point.CONCLUSIONS: These data indicate that stimulation of dopamine D1 receptors reduces alcohol intake, but that endogenous dopamine does not play a primary role in alcohol consumption. Moreover, the difference in alcohol consumption between LD and HD does not involve altered dopamine signaling.

KW - Addiction

KW - Alcohol

KW - Dopamine receptor

KW - Individual differences

U2 - 10.1007/s00213-016-4330-x

DO - 10.1007/s00213-016-4330-x

M3 - Article

C2 - 27236784

SN - 0033-3158

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JO - Psychopharmacology

JF - Psychopharmacology

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ER -

Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats

Abstract

Keywords

UN SDGs

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