OBJECTIVES: To analyse the cardiovascular disease risk profile of women with fibromyalgia and compare it with control women; and to test whether physical activity is associated with the cardiovascular disease risk profile in this population.

METHODS: This cross-sectional study comprised 436 women with fibromyalgia (51.4±7.5 years old) and 217 controls (48.4±9.6 years old) from Andalusia, Spain. Clinical data, waist circumference, body fat percentage, resting heart rate, blood pressure and cardiorespiratory fitness were assessed. Moderate-to-vigorous physical activity was objectively assessed with accelerometry. A clustering of individual cardiovascular disease risk factors was represented by the number of cigarettes/day, adiposity, mean arterial pressure, resting heart rate and cardiorespiratory fitness.

RESULTS: Women with fibromyalgia presented higher waist circumference and body fat percentage, greater number of cigarettes/day consumption and lower levels of cardiorespiratory fitness after controlling for age, marital status, educational level, occupational status, medication for cholesterol and monthly regular menstruation (all, p<.05). Women with fibromyalgia showed higher clustered cardiovascular disease risk than control women after controlling for the potential confounders described above (p<.001). Women with fibromyalgia who did not meet moderate-to-vigorous physical activity recommendations showed increased clustered cardiovascular disease risk after adjusting for the potential confounders described above (p<.001).

CONCLUSIONS: Women with fibromyalgia may present higher risk of cardiovascular disease than controls. Inadequate levels of moderate-to-vigorous physical activity may play a significant role as an additional predisposing factor for cardiovascular disease risk in this population.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalClinical and Experimental Rheumatology
Volume35 Suppl 105
Issue number3
Publication statusPublished - 14 Apr 2017


  • Accelerometry
  • Adipose Tissue
  • Adiposity
  • Adult
  • Arterial Pressure
  • Blood Pressure
  • Cardiorespiratory Fitness
  • Cardiovascular Diseases
  • Case-Control Studies
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Exercise
  • Female
  • Fibromyalgia
  • Heart Rate
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Middle Aged
  • Obesity
  • Smoking
  • Spain
  • Waist Circumference


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