Do Endorphins Mediate Placebo Analgesia?: A Critical Commentary on One of the Seminal Papers

G. ter Riet; A.J.M. de Craen; Anthonius de Boer; J. Kessels; Anthonius de Boer

doi:21069

Do Endorphins Mediate Placebo Analgesia? A Critical Commentary on One of the Seminal Papers

G. ter Riet, A.J.M. de Craen, Anthonius de Boer, J. Kessels, Anthonius de Boer

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Abstract

There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.

Original language	English
Pages (from-to)	12-14
Number of pages	3
Journal	Forschende Komplementarmedizin
Volume	5 Suppl S1
DOIs	https://doi.org/21069
Publication status	Published - 1998

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21069

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title = "Do Endorphins Mediate Placebo Analgesia?: A Critical Commentary on One of the Seminal Papers",

abstract = "There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.",

author = "{ter Riet}, G. and {de Craen}, A.J.M. and {de Boer}, Anthonius and J. Kessels and {de Boer}, Anthonius",

year = "1998",

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AU - Kessels, J.

AU - de Boer, Anthonius

PY - 1998

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N2 - There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.

AB - There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.

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C2 - 9892824

SN - 1021-7096

VL - 5 Suppl S1

SP - 12

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JO - Forschende Komplementarmedizin

JF - Forschende Komplementarmedizin

ER -

Do Endorphins Mediate Placebo Analgesia? A Critical Commentary on One of the Seminal Papers

Abstract

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