Abstract
Solid-state nuclear magnetic resonance (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity. Revolutionary developments in the field of dynamic nuclear polarization (DNP) have greatly enhanced ssNMR sensitivity. In this article, we discuss ssNMR concepts and applications that make use of these advancements and enable the study of complex biomolecular and even cellular systems at unprecedented structural resolution and molecular detail.
| Original language | English |
|---|---|
| Pages (from-to) | 51-62 |
| Number of pages | 12 |
| Journal | eMagRes |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Funding
We gratefully acknowledge our collaborators and colleagues for their invaluable contributions to cited publications from our own research group. These studies were supported through grants from NWO, the EU and NIH as well as the DFG, the Max-Planck-Society and the Volkswagen foundation.
Keywords
- Bacterial cell envelope
- DNP
- MAS
- Membrane proteins
- Solid-state NMR