Abstract
Inspired by nanotechnologies based on DNA strand displacement, herein we demonstrate that synthetic helical strand exchange can be achieved through tuning of poly(methyl methacrylate) (PMMA) triple-helix stereocomplexes. To evaluate the utility and robustness of helical strand exchange, stereoregular PMMA/polyethylene glycol (PEG) block copolymers capable of undergoing crystallization driven self-assembly via stereocomplex formation were prepared. Micelles with spherical or wormlike morphologies were formed by varying the molecular weight composition of the assembling components. Significantly, PMMA strand exchange was demonstrated and utilized to reversibly switch the micelles between different morphologies. This concept of strand exchange with PMMA-based triple-helix stereocomplexes offers new opportunities to program dynamic behaviors of polymeric materials, leading to scalable synthesis of "smart" nanosystems.
| Original language | English |
|---|---|
| Pages (from-to) | 2630-2635 |
| Number of pages | 6 |
| Journal | Journal of the American Chemical Society |
| Volume | 141 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 13 Feb 2019 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work was supported primarily by the National Science Foundation (MRSEC program − DMR 1720256). J.M.R. thanks the Victorian Endowment for Science, Knowledge and Innovation (VESKI) for a postdoctoral fellowship. A.S.K. was supported by a postdoctoral fellowship from the Arnold and Mabel Beckman Foundation. The authors thank Adam Levi and the Bates research group at UC Santa Barbara for SAXS measurements.
Funding Information:
This work was supported primarily by the National Science Foundation (MRSEC program DMR 1720256). J.M.R. thanks the Victorian Endowment for Science, Knowledge and Innovation (VESKI) for a postdoctoral fellowship.
Publisher Copyright:
© 2019 American Chemical Society.
Funding
This work was supported primarily by the National Science Foundation (MRSEC program − DMR 1720256). J.M.R. thanks the Victorian Endowment for Science, Knowledge and Innovation (VESKI) for a postdoctoral fellowship. A.S.K. was supported by a postdoctoral fellowship from the Arnold and Mabel Beckman Foundation. The authors thank Adam Levi and the Bates research group at UC Santa Barbara for SAXS measurements. This work was supported primarily by the National Science Foundation (MRSEC program DMR 1720256). J.M.R. thanks the Victorian Endowment for Science, Knowledge and Innovation (VESKI) for a postdoctoral fellowship.