Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers

J W Krulder; A de Boer; A M van den Besselaar; A F Cohen; H C Schoemaker; E Briët; A E Meinders

Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers

J W Krulder, A de Boer, A M van den Besselaar, A F Cohen, H C Schoemaker, E Briët, A E Meinders

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The objective of the study was to investigate possible diurnal rhythms in coagulation tests during a continuous intravenous infusion of unfractionated heparin. Six volunteers participated in the study, which was divided in a treatment (500 U heparin/h for 30 h) and a control experiment. Under basal conditions, no rhythm was found in coagulation tests. During heparin treatment, APTT, thrombin clotting time and anti-Xa activity showed a greater anticoagulant effect at night, with a striking decrease in the morning. In a search for the explanation of this phenomenon we looked for diurnal variations in the urinary excretion of heparin, in the plasma concentrations of antithrombin III and platelet factor 4, and in the effect of heparin added to the plasma samples in vitro. None of these studies provided the explanation.

Original language	English
Pages (from-to)	30-2
Number of pages	3
Journal	Thrombosis and Haemostasis
Volume	68
Issue number	1
Publication status	Published - 6 Jul 1992

Keywords

Adult
Circadian Rhythm
Heparin
Humans
Infusions, Intravenous
Male
Partial Thromboplastin Time

Cite this

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title = "Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers",

abstract = "The objective of the study was to investigate possible diurnal rhythms in coagulation tests during a continuous intravenous infusion of unfractionated heparin. Six volunteers participated in the study, which was divided in a treatment (500 U heparin/h for 30 h) and a control experiment. Under basal conditions, no rhythm was found in coagulation tests. During heparin treatment, APTT, thrombin clotting time and anti-Xa activity showed a greater anticoagulant effect at night, with a striking decrease in the morning. In a search for the explanation of this phenomenon we looked for diurnal variations in the urinary excretion of heparin, in the plasma concentrations of antithrombin III and platelet factor 4, and in the effect of heparin added to the plasma samples in vitro. None of these studies provided the explanation.",

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T1 - Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers

AU - Krulder, J W

AU - de Boer, A

AU - van den Besselaar, A M

AU - Cohen, A F

AU - Schoemaker, H C

AU - Briët, E

AU - Meinders, A E

PY - 1992/7/6

Y1 - 1992/7/6

N2 - The objective of the study was to investigate possible diurnal rhythms in coagulation tests during a continuous intravenous infusion of unfractionated heparin. Six volunteers participated in the study, which was divided in a treatment (500 U heparin/h for 30 h) and a control experiment. Under basal conditions, no rhythm was found in coagulation tests. During heparin treatment, APTT, thrombin clotting time and anti-Xa activity showed a greater anticoagulant effect at night, with a striking decrease in the morning. In a search for the explanation of this phenomenon we looked for diurnal variations in the urinary excretion of heparin, in the plasma concentrations of antithrombin III and platelet factor 4, and in the effect of heparin added to the plasma samples in vitro. None of these studies provided the explanation.

AB - The objective of the study was to investigate possible diurnal rhythms in coagulation tests during a continuous intravenous infusion of unfractionated heparin. Six volunteers participated in the study, which was divided in a treatment (500 U heparin/h for 30 h) and a control experiment. Under basal conditions, no rhythm was found in coagulation tests. During heparin treatment, APTT, thrombin clotting time and anti-Xa activity showed a greater anticoagulant effect at night, with a striking decrease in the morning. In a search for the explanation of this phenomenon we looked for diurnal variations in the urinary excretion of heparin, in the plasma concentrations of antithrombin III and platelet factor 4, and in the effect of heparin added to the plasma samples in vitro. None of these studies provided the explanation.

KW - Adult

KW - Circadian Rhythm

KW - Heparin

KW - Humans

KW - Infusions, Intravenous

KW - Male

KW - Partial Thromboplastin Time

M3 - Article

C2 - 1514169

SN - 0340-6245

VL - 68

SP - 30

EP - 32

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

IS - 1

ER -

Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers

Abstract

Keywords

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