Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model

Ronald Vlasblom*, Jory van Thiel, Mátyás A Bittenbinder, Jon-Ruben van Rhijn, Rinske Drost, Lotte Muis, Julien Slagboom, Daniela Salvatori, Jeroen Kool, Robert Jan Veldman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.

Original languageEnglish
Article number107637
Number of pages5
JournalToxicon
Volume240
Early online date6 Feb 2024
DOIs
Publication statusPublished - Mar 2024

Keywords

  • Cardiotoxicity
  • Cardiovascular system
  • Langendorff heart
  • Snakebite
  • Venom

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