TY - JOUR
T1 - Differential sensitivity of Rauscher murine leukaemia virus (MuLV-R) to interferons in two interferon responsive cell lines
AU - Allen, P. T.
AU - Schellekens, H.
AU - Van Griensven, L. J.L.D.
AU - Billiau, A.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - The effect of interferon on the replication of vesicular stomatitis virus (VSV) and type C oncornavirus in 2 Balb/c mouse bone marrow cell lines, JLS V5 and JLS V9R, infected with MuLV R was examined. VSV replication was inhibited threefold (0.5 log 10) in both cell lines by 10 to 20 units of interferon/ml. In JLS V5 cells C type virus yields, as measured by 3H uridine incorporation and reverse transcriptase activity, were also reduced threefold by 10 to 20 units of interferon/ml. However, in JLS V9R cells, C type virus replication was refractory to interferon at concentrations up to 1x104 units/ml. Infectious C type virus transmitted from JLS V9R cells to Balb/3T3 cells was as sensitive to interferon as virus transmitted from JLS V5 cells, indicating that resistance of C type virus in JLS V9R cells is a feature of the cells rather than of the virus strain.
AB - The effect of interferon on the replication of vesicular stomatitis virus (VSV) and type C oncornavirus in 2 Balb/c mouse bone marrow cell lines, JLS V5 and JLS V9R, infected with MuLV R was examined. VSV replication was inhibited threefold (0.5 log 10) in both cell lines by 10 to 20 units of interferon/ml. In JLS V5 cells C type virus yields, as measured by 3H uridine incorporation and reverse transcriptase activity, were also reduced threefold by 10 to 20 units of interferon/ml. However, in JLS V9R cells, C type virus replication was refractory to interferon at concentrations up to 1x104 units/ml. Infectious C type virus transmitted from JLS V9R cells to Balb/3T3 cells was as sensitive to interferon as virus transmitted from JLS V5 cells, indicating that resistance of C type virus in JLS V9R cells is a feature of the cells rather than of the virus strain.
UR - http://www.scopus.com/inward/record.url?scp=0017123887&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-31-3-429
DO - 10.1099/0022-1317-31-3-429
M3 - Article
C2 - 58965
AN - SCOPUS:0017123887
SN - 0022-1317
VL - 31
SP - 429
EP - 435
JO - Journal of General Virology
JF - Journal of General Virology
IS - 3
ER -