Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

W Widagdo; V Stalin Raj; Debby Schipper; Kimberley Kolijn; Geert J L H van Leenders; Berend J Bosch; Albert Bensaid; Joaquim Segalés; Wolfgang Baumgärtner; Albert D M E Osterhaus; Marion P Koopmans; Judith M A van den Brand; Bart L Haagmans

doi:10.1128/JVI.02994-15

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

W Widagdo, V Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert J L H van Leenders, Berend J Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert D M E Osterhaus, Marion P Koopmans, Judith M A van den Brand, Bart L Haagmans^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract, hence restrict transmission.

Original language	English
Pages (from-to)	4838-4842
Number of pages	5
Journal	Journal of Virology
Volume	90
Issue number	9
DOIs	https://doi.org/10.1128/JVI.02994-15
Publication status	Published - May 2016

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Widagdo, W., Raj, V. S., Schipper, D., Kolijn, K., van Leenders, G. J. L. H., Bosch, B. J., Bensaid, A., Segalés, J., Baumgärtner, W., Osterhaus, A. D. M. E., Koopmans, M. P., van den Brand, J. M. A., & Haagmans, B. L. (2016). Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. Journal of Virology, 90(9), 4838-4842. https://doi.org/10.1128/JVI.02994-15

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title = "Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels",

abstract = "Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract, hence restrict transmission.",

author = "W Widagdo and Raj, {V Stalin} and Debby Schipper and Kimberley Kolijn and {van Leenders}, {Geert J L H} and Bosch, {Berend J} and Albert Bensaid and Joaquim Segal{\'e}s and Wolfgang Baumg{\"a}rtner and Osterhaus, {Albert D M E} and Koopmans, {Marion P} and {van den Brand}, {Judith M A} and Haagmans, {Bart L}",

year = "2016",

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doi = "10.1128/JVI.02994-15",

language = "English",

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Widagdo, W, Raj, VS, Schipper, D, Kolijn, K, van Leenders, GJLH, Bosch, BJ, Bensaid, A, Segalés, J, Baumgärtner, W, Osterhaus, ADME, Koopmans, MP, van den Brand, JMA & Haagmans, BL 2016, 'Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels', Journal of Virology, vol. 90, no. 9, pp. 4838-4842. https://doi.org/10.1128/JVI.02994-15

TY - JOUR

T1 - Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

AU - Widagdo, W

AU - Raj, V Stalin

AU - Schipper, Debby

AU - Kolijn, Kimberley

AU - van Leenders, Geert J L H

AU - Bosch, Berend J

AU - Bensaid, Albert

AU - Segalés, Joaquim

AU - Baumgärtner, Wolfgang

AU - Osterhaus, Albert D M E

AU - Koopmans, Marion P

AU - van den Brand, Judith M A

AU - Haagmans, Bart L

PY - 2016/5

Y1 - 2016/5

N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract, hence restrict transmission.

AB - Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract, hence restrict transmission.

U2 - 10.1128/JVI.02994-15

DO - 10.1128/JVI.02994-15

M3 - Article

C2 - 26889022

SN - 0022-538X

VL - 90

SP - 4838

EP - 4842

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

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