Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

Talip E. Eroglu; Grimur H. Mohr; Marieke T. Blom; Arie O. Verkerk; Patrick C. Souverein; Christian Torp-Pedersen; Fredrik Folke; Mads Wissenberg; Lettine van den Brink; Richard P. Davis; Anthonius de Boer; Gunnar H. Gislason; Hanno L. Tan

doi:10.1093/ehjcvp/pvz038

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

Talip E. Eroglu, Grimur H. Mohr, Marieke T. Blom, Arie O. Verkerk, Patrick C. Souverein, Christian Torp-Pedersen, Fredrik Folke, Mads Wissenberg, Lettine van den Brink, Richard P. Davis, Anthonius de Boer, Gunnar H. Gislason, Hanno L. Tan

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIMS: Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. METHODS AND RESULTS: We conducted a case-control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine (

Original language	English
Pages (from-to)	347-355
Number of pages	9
Journal	European heart journal. Cardiovascular pharmacotherapy
Volume	6
DOIs	https://doi.org/10.1093/ehjcvp/pvz038
Publication status	Published - Nov 2020

Keywords

Amlodipine
Epidemiology
Nifedipine
Sudden cardiac arrest
action potential
adult
article
calcium current
cardiac muscle cell
case control study
controlled study
Denmark
drug effect
drug megadose
female
heart electrophysiology
heart ventricle tachycardia
human
human cell
induced pluripotent stem cell
ischemic heart disease
low drug dose
major clinical study
male
Netherlands
out of hospital cardiac arrest
patch clamp technique
sudden cardiac death
titrimetry
amlodipine
calcium channel L type
endogenous compound
nifedipine
nitric acid derivative

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10.1093/ehjcvp/pvz038

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Eroglu, T. E., Mohr, G. H., Blom, M. T., Verkerk, A. O., Souverein, P. C., Torp-Pedersen, C., Folke, F., Wissenberg, M., van den Brink, L., Davis, R. P., de Boer, A., Gislason, G. H., & Tan, H. L. (2020). Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries. European heart journal. Cardiovascular pharmacotherapy, 6, 347-355. https://doi.org/10.1093/ehjcvp/pvz038

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title = "Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries",

abstract = "AIMS: Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. METHODS AND RESULTS: We conducted a case-control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine (",

keywords = "Amlodipine, Epidemiology, Nifedipine, Sudden cardiac arrest, action potential, adult, article, calcium current, cardiac muscle cell, case control study, controlled study, Denmark, drug effect, drug megadose, female, heart electrophysiology, heart ventricle tachycardia, human, human cell, induced pluripotent stem cell, ischemic heart disease, low drug dose, major clinical study, male, Netherlands, out of hospital cardiac arrest, patch clamp technique, sudden cardiac death, titrimetry, amlodipine, calcium channel L type, endogenous compound, nifedipine, nitric acid derivative",

author = "Eroglu, {Talip E.} and Mohr, {Grimur H.} and Blom, {Marieke T.} and Verkerk, {Arie O.} and Souverein, {Patrick C.} and Christian Torp-Pedersen and Fredrik Folke and Mads Wissenberg and {van den Brink}, Lettine and Davis, {Richard P.} and {de Boer}, Anthonius and Gislason, {Gunnar H.} and Tan, {Hanno L.}",

year = "2020",

month = nov,

doi = "10.1093/ehjcvp/pvz038",

language = "English",

volume = "6",

pages = "347--355",

journal = "European heart journal. Cardiovascular pharmacotherapy",

issn = "2055-6845",

publisher = "Oxford University Press",

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Eroglu, TE, Mohr, GH, Blom, MT, Verkerk, AO, Souverein, PC, Torp-Pedersen, C, Folke, F, Wissenberg, M, van den Brink, L, Davis, RP, de Boer, A, Gislason, GH & Tan, HL 2020, 'Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries', European heart journal. Cardiovascular pharmacotherapy, vol. 6, pp. 347-355. https://doi.org/10.1093/ehjcvp/pvz038

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries. / Eroglu, Talip E.; Mohr, Grimur H.; Blom, Marieke T. et al.
In: European heart journal. Cardiovascular pharmacotherapy, Vol. 6, 11.2020, p. 347-355.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Differential effects on out-of-hospital cardiac arrest of dihydropyridines

T2 - real-world data from population-based cohorts across two European countries

AU - Eroglu, Talip E.

AU - Mohr, Grimur H.

AU - Blom, Marieke T.

AU - Verkerk, Arie O.

AU - Souverein, Patrick C.

AU - Torp-Pedersen, Christian

AU - Folke, Fredrik

AU - Wissenberg, Mads

AU - van den Brink, Lettine

AU - Davis, Richard P.

AU - de Boer, Anthonius

AU - Gislason, Gunnar H.

AU - Tan, Hanno L.

PY - 2020/11

Y1 - 2020/11

N2 - AIMS: Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. METHODS AND RESULTS: We conducted a case-control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine (

AB - AIMS: Various drugs increase the risk of out-of-hospital cardiac arrest (OHCA) in the general population by impacting cardiac ion channels, thereby causing ventricular tachycardia/fibrillation (VT/VF). Dihydropyridines block L-type calcium channels, but their association with OHCA risk is unknown. We aimed to study whether nifedipine and/or amlodipine, often-used dihydropyridines, are associated with increased OHCA risk, and how these drugs impact on cardiac electrophysiology. METHODS AND RESULTS: We conducted a case-control study with VT/VF-documented OHCA cases with presumed cardiac cause from ongoing population-based OHCA registries in the Netherlands and Denmark, and age/sex/index date-matched non-OHCA controls (Netherlands: PHARMO Database Network, Denmark: Danish Civil Registration System). We included 2503 OHCA cases, 10 543 non-OHCA controls in Netherlands, and 8101 OHCA cases, 40 505 non-OHCA controls in Denmark. To examine drug effects on cardiac electrophysiology, we performed single-cell patch-clamp studies in human-induced pluripotent stem cell-derived cardiomyocytes. Use of high-dose nifedipine (≥60 mg/day), but not low-dose nifedipine (

KW - Amlodipine

KW - Epidemiology

KW - Nifedipine

KW - Sudden cardiac arrest

KW - action potential

KW - adult

KW - article

KW - calcium current

KW - cardiac muscle cell

KW - case control study

KW - controlled study

KW - Denmark

KW - drug effect

KW - drug megadose

KW - female

KW - heart electrophysiology

KW - heart ventricle tachycardia

KW - human

KW - human cell

KW - induced pluripotent stem cell

KW - ischemic heart disease

KW - low drug dose

KW - major clinical study

KW - male

KW - Netherlands

KW - out of hospital cardiac arrest

KW - patch clamp technique

KW - sudden cardiac death

KW - titrimetry

KW - amlodipine

KW - calcium channel L type

KW - endogenous compound

KW - nifedipine

KW - nitric acid derivative

U2 - 10.1093/ehjcvp/pvz038

DO - 10.1093/ehjcvp/pvz038

M3 - Article

SN - 2055-6845

VL - 6

SP - 347

EP - 355

JO - European heart journal. Cardiovascular pharmacotherapy

JF - European heart journal. Cardiovascular pharmacotherapy

ER -

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

Abstract

Keywords

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