Differential effects of fibroblast and leucocyte interferon in HBsAg positive chronic active hepatitis

W. WEIMAR; R. A. HEIJTINK; S. W. SCHALM; H. SCHELLEKENS

doi:10.1111/j.1365-2362.1979.tb01682.x

Differential effects of fibroblast and leucocyte interferon in HBsAg positive chronic active hepatitis

W. WEIMAR^*, R. A. HEIJTINK, S. W. SCHALM, H. SCHELLEKENS

^*Corresponding author for this work

Erasmus University Rotterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Abstract. Six patients with hepatitis B surface antigen, hepatitis B ‘e’ antigen positive chronic active hepatitis, and elevated hepatitis B specific DNA polymerase activity were treated sequentially with fibroblast and leucocyte interferon. Fibroblast interferon induced a fall in serum transaminase activities in all patients, whereas a consistent decline in DNA polymerase activity was observed during leucocyte interferon administration only. After treatment one patient remained persistently DNA polymerase and hepatitis B ‘e’ antigen negative, whereas relapse to initial values occurred in others. Side effects included severe but reversible granulocytopenia, and chills responding to promethazine treatment. The differential biological activity of fibroblast and leucocyte interferon in our patients coincides with their non‐identity in in vitro studies.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	European Journal of Clinical Investigation
Volume	9
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2362.1979.tb01682.x
Publication status	Published - 1 Jan 1979

Keywords

chronic active hepatitis
Fibroblast interferon
leucocyte interferon

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10.1111/j.1365-2362.1979.tb01682.x

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title = "Differential effects of fibroblast and leucocyte interferon in HBsAg positive chronic active hepatitis",

abstract = "Abstract. Six patients with hepatitis B surface antigen, hepatitis B {\textquoteleft}e{\textquoteright} antigen positive chronic active hepatitis, and elevated hepatitis B specific DNA polymerase activity were treated sequentially with fibroblast and leucocyte interferon. Fibroblast interferon induced a fall in serum transaminase activities in all patients, whereas a consistent decline in DNA polymerase activity was observed during leucocyte interferon administration only. After treatment one patient remained persistently DNA polymerase and hepatitis B {\textquoteleft}e{\textquoteright} antigen negative, whereas relapse to initial values occurred in others. Side effects included severe but reversible granulocytopenia, and chills responding to promethazine treatment. The differential biological activity of fibroblast and leucocyte interferon in our patients coincides with their non‐identity in in vitro studies.",

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T1 - Differential effects of fibroblast and leucocyte interferon in HBsAg positive chronic active hepatitis

AU - WEIMAR, W.

AU - HEIJTINK, R. A.

AU - SCHALM, S. W.

AU - SCHELLEKENS, H.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Abstract. Six patients with hepatitis B surface antigen, hepatitis B ‘e’ antigen positive chronic active hepatitis, and elevated hepatitis B specific DNA polymerase activity were treated sequentially with fibroblast and leucocyte interferon. Fibroblast interferon induced a fall in serum transaminase activities in all patients, whereas a consistent decline in DNA polymerase activity was observed during leucocyte interferon administration only. After treatment one patient remained persistently DNA polymerase and hepatitis B ‘e’ antigen negative, whereas relapse to initial values occurred in others. Side effects included severe but reversible granulocytopenia, and chills responding to promethazine treatment. The differential biological activity of fibroblast and leucocyte interferon in our patients coincides with their non‐identity in in vitro studies.

AB - Abstract. Six patients with hepatitis B surface antigen, hepatitis B ‘e’ antigen positive chronic active hepatitis, and elevated hepatitis B specific DNA polymerase activity were treated sequentially with fibroblast and leucocyte interferon. Fibroblast interferon induced a fall in serum transaminase activities in all patients, whereas a consistent decline in DNA polymerase activity was observed during leucocyte interferon administration only. After treatment one patient remained persistently DNA polymerase and hepatitis B ‘e’ antigen negative, whereas relapse to initial values occurred in others. Side effects included severe but reversible granulocytopenia, and chills responding to promethazine treatment. The differential biological activity of fibroblast and leucocyte interferon in our patients coincides with their non‐identity in in vitro studies.

KW - chronic active hepatitis

KW - Fibroblast interferon

KW - leucocyte interferon

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Differential effects of fibroblast and leucocyte interferon in HBsAg positive chronic active hepatitis

Abstract

Keywords

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