Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model

P.V. Jeurink; J. Kerperien; T.M.D. Wehkamp; E.C.A.M. Van Esch; A. Rijnierse; G.A. Hofman; L.E.M. Willemsen; J. Garssen; L.M.J. Knippels

doi:10.1016/j.jaci.2011.12.812

Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model

P.V. Jeurink, J. Kerperien, T.M.D. Wehkamp, E.C.A.M. Van Esch, A. Rijnierse, G.A. Hofman, L.E.M. Willemsen, J. Garssen, L.M.J. Knippels

Pharmacology

Danone S.A.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

RATIONALE: In this study, the effects of dietary supplementation with specific non-digestible oligosaccharides (prebiotics) either as single components or in mixtures on the outcome of the murine allergic response when provided before and during oral sensitization with whey were investigated. In addition, the feasibility to treat allergic mice with these prebiotics was addressed. METHODS: Mice were fed diets containing 1% single prebiotics, combinations of scGOS (short chain galacto-oligosaccharides), lcFOS (long chain fructo- oligosaccharides) and/or pAOS (pectin-derived acidic oligosaccharides) or a control diet. The diets were provided two weeks prior to and during oral whey-sensitization (prevention) or for four weeks starting one week after the last sensitization (treatment). The acute allergic skin response (ITH) and antigen-induced anaphylaxis (AiA) were determined one hour after intradermal whey-challenge. Whey-IgE/G1/G2a and mouse mast cell protease-1 (mMCP-1) were determined in serum. RESULTS: In the whey-sensitized preventive intervention groups, only combination of scGOS/lcFOS (9:1) and scGOS/lcFOS/pAOS (9:1:2) strongly reduced both ITH (p

Original language	English
Pages (from-to)	40
Number of pages	1
Journal	Journal of Allergy and Clinical Immunology
Volume	129
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2011.12.812
Publication status	Published - 1 Feb 2012

Keywords

oligosaccharide
prebiotic agent
immunoglobulin E
brinase
galactose oligosaccharide
fructose oligosaccharide
pectin
antigen
allergic disease
immunology
allergic asthma
milk allergy
disease model
whey
diet
mouse
sensitization
diet supplementation
prevention
serum
allergic reaction
skin
anaphylaxis
mast cell
allergy
model
hypersensitivity

Access to Document

10.1016/j.jaci.2011.12.812

Cite this

Jeurink, P. V., Kerperien, J., Wehkamp, T. M. D., Van Esch, E. C. A. M., Rijnierse, A., Hofman, G. A., Willemsen, L. E. M., Garssen, J., & Knippels, L. M. J. (2012). Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model. Journal of Allergy and Clinical Immunology, 129(2), 40. https://doi.org/10.1016/j.jaci.2011.12.812

@article{2e2eb84434ff4afcaeb61a816eefb356,

title = "Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model",

abstract = "RATIONALE: In this study, the effects of dietary supplementation with specific non-digestible oligosaccharides (prebiotics) either as single components or in mixtures on the outcome of the murine allergic response when provided before and during oral sensitization with whey were investigated. In addition, the feasibility to treat allergic mice with these prebiotics was addressed. METHODS: Mice were fed diets containing 1% single prebiotics, combinations of scGOS (short chain galacto-oligosaccharides), lcFOS (long chain fructo- oligosaccharides) and/or pAOS (pectin-derived acidic oligosaccharides) or a control diet. The diets were provided two weeks prior to and during oral whey-sensitization (prevention) or for four weeks starting one week after the last sensitization (treatment). The acute allergic skin response (ITH) and antigen-induced anaphylaxis (AiA) were determined one hour after intradermal whey-challenge. Whey-IgE/G1/G2a and mouse mast cell protease-1 (mMCP-1) were determined in serum. RESULTS: In the whey-sensitized preventive intervention groups, only combination of scGOS/lcFOS (9:1) and scGOS/lcFOS/pAOS (9:1:2) strongly reduced both ITH (p",

keywords = "oligosaccharide, prebiotic agent, immunoglobulin E, brinase, galactose oligosaccharide, fructose oligosaccharide, pectin, antigen, allergic disease, immunology, allergic asthma, milk allergy, disease model, whey, diet, mouse, sensitization, diet supplementation, prevention, serum, allergic reaction, skin, anaphylaxis, mast cell, allergy, model, hypersensitivity",

author = "P.V. Jeurink and J. Kerperien and T.M.D. Wehkamp and {Van Esch}, E.C.A.M. and A. Rijnierse and G.A. Hofman and L.E.M. Willemsen and J. Garssen and L.M.J. Knippels",

year = "2012",

month = feb,

day = "1",

doi = "10.1016/j.jaci.2011.12.812",

language = "English",

volume = "129",

pages = "40",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "2",

}

Jeurink, PV, Kerperien, J, Wehkamp, TMD , Van Esch, ECAM, Rijnierse, A, Hofman, GA, Willemsen, LEM , Garssen, J & Knippels, LMJ 2012, 'Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model', Journal of Allergy and Clinical Immunology, vol. 129, no. 2, pp. 40. https://doi.org/10.1016/j.jaci.2011.12.812

Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model. / Jeurink, P.V.; Kerperien, J.; Wehkamp, T.M.D. et al.
In: Journal of Allergy and Clinical Immunology, Vol. 129, No. 2, 01.02.2012, p. 40.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model

AU - Jeurink, P.V.

AU - Kerperien, J.

AU - Wehkamp, T.M.D.

AU - Van Esch, E.C.A.M.

AU - Rijnierse, A.

AU - Hofman, G.A.

AU - Willemsen, L.E.M.

AU - Garssen, J.

AU - Knippels, L.M.J.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - RATIONALE: In this study, the effects of dietary supplementation with specific non-digestible oligosaccharides (prebiotics) either as single components or in mixtures on the outcome of the murine allergic response when provided before and during oral sensitization with whey were investigated. In addition, the feasibility to treat allergic mice with these prebiotics was addressed. METHODS: Mice were fed diets containing 1% single prebiotics, combinations of scGOS (short chain galacto-oligosaccharides), lcFOS (long chain fructo- oligosaccharides) and/or pAOS (pectin-derived acidic oligosaccharides) or a control diet. The diets were provided two weeks prior to and during oral whey-sensitization (prevention) or for four weeks starting one week after the last sensitization (treatment). The acute allergic skin response (ITH) and antigen-induced anaphylaxis (AiA) were determined one hour after intradermal whey-challenge. Whey-IgE/G1/G2a and mouse mast cell protease-1 (mMCP-1) were determined in serum. RESULTS: In the whey-sensitized preventive intervention groups, only combination of scGOS/lcFOS (9:1) and scGOS/lcFOS/pAOS (9:1:2) strongly reduced both ITH (p

AB - RATIONALE: In this study, the effects of dietary supplementation with specific non-digestible oligosaccharides (prebiotics) either as single components or in mixtures on the outcome of the murine allergic response when provided before and during oral sensitization with whey were investigated. In addition, the feasibility to treat allergic mice with these prebiotics was addressed. METHODS: Mice were fed diets containing 1% single prebiotics, combinations of scGOS (short chain galacto-oligosaccharides), lcFOS (long chain fructo- oligosaccharides) and/or pAOS (pectin-derived acidic oligosaccharides) or a control diet. The diets were provided two weeks prior to and during oral whey-sensitization (prevention) or for four weeks starting one week after the last sensitization (treatment). The acute allergic skin response (ITH) and antigen-induced anaphylaxis (AiA) were determined one hour after intradermal whey-challenge. Whey-IgE/G1/G2a and mouse mast cell protease-1 (mMCP-1) were determined in serum. RESULTS: In the whey-sensitized preventive intervention groups, only combination of scGOS/lcFOS (9:1) and scGOS/lcFOS/pAOS (9:1:2) strongly reduced both ITH (p

KW - oligosaccharide

KW - prebiotic agent

KW - immunoglobulin E

KW - brinase

KW - galactose oligosaccharide

KW - fructose oligosaccharide

KW - pectin

KW - antigen

KW - allergic disease

KW - immunology

KW - allergic asthma

KW - milk allergy

KW - disease model

KW - whey

KW - diet

KW - mouse

KW - sensitization

KW - diet supplementation

KW - prevention

KW - serum

KW - allergic reaction

KW - skin

KW - anaphylaxis

KW - mast cell

KW - allergy

KW - model

KW - hypersensitivity

U2 - 10.1016/j.jaci.2011.12.812

DO - 10.1016/j.jaci.2011.12.812

M3 - Article

SN - 0091-6749

VL - 129

SP - 40

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2

ER -

Jeurink PV, Kerperien J, Wehkamp TMD , Van Esch ECAM, Rijnierse A, Hofman GA et al. Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model. Journal of Allergy and Clinical Immunology. 2012 Feb 1;129(2):40. doi: 10.1016/j.jaci.2011.12.812

Dietary intervention with specific non-digestible oligosaccharide mixtures is effective during induction Of Murine cow's milk allergy but not suitable as treatment in the same allergic disease model

Abstract

Keywords

Access to Document

Fingerprint

Cite this