Abstract
The etiology of leukemias cannot entirely be explained by known
risk factors, including ionizing radiation, benzene exposure, and
infection with human T cell leukemia virus. A number of studies
suggested that diet influences the risk of adult leukemias. However,
results have been largely inconsistent. We examined the potential
association between dietary factors and risk of leukemias
among participants of the European Prospective Investigation into
Cancer and Nutrition study. Among the 477,325 participants with
mean follow-up of 11.34 yr (SD = 2.47), 773 leukemias (373 and
342 cases of lymphoid and myeloid leukemia, respectively) were
identified. Diet over the previous 12 mo was assessed at baseline using a validated country-specific dietary questionnaire. Cox proportional
hazards regression was used to explore the association
between dietary factors that have previously been associated with
leukemia risk, including red and processed meat, poultry, offal,
fish, dairy products, vegetables, fruits, and seeds/nuts, and risk of
both lymphoid and myeloid leukemias. No significant associations
were observed between dietary measures and total, lymphoid, and
myeloid leukemias. Additional subtype analyses showed no dietary
association with risk of major subtypes of leukemias. In summary,
this study did not support a possible link between selected dietary
factors and risk of leukemias.
risk factors, including ionizing radiation, benzene exposure, and
infection with human T cell leukemia virus. A number of studies
suggested that diet influences the risk of adult leukemias. However,
results have been largely inconsistent. We examined the potential
association between dietary factors and risk of leukemias
among participants of the European Prospective Investigation into
Cancer and Nutrition study. Among the 477,325 participants with
mean follow-up of 11.34 yr (SD = 2.47), 773 leukemias (373 and
342 cases of lymphoid and myeloid leukemia, respectively) were
identified. Diet over the previous 12 mo was assessed at baseline using a validated country-specific dietary questionnaire. Cox proportional
hazards regression was used to explore the association
between dietary factors that have previously been associated with
leukemia risk, including red and processed meat, poultry, offal,
fish, dairy products, vegetables, fruits, and seeds/nuts, and risk of
both lymphoid and myeloid leukemias. No significant associations
were observed between dietary measures and total, lymphoid, and
myeloid leukemias. Additional subtype analyses showed no dietary
association with risk of major subtypes of leukemias. In summary,
this study did not support a possible link between selected dietary
factors and risk of leukemias.
| Original language | English |
|---|---|
| Pages (from-to) | 14-28 |
| Number of pages | 15 |
| Journal | Nutrition and Cancer |
| Volume | 66 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |