Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

S G Yammine; I Huybrechts; C Biessy; L Dossus; S Panico; M J Sánchez; V Benetou; R Turzanski-Fortner; V Katzke; A Idahl; G Skeie; K Standahl Olsen; A Tjønneland; J Halkjaer; S Colorado-Yohar; A K Heath; E Sonestedt; H Sartor; M B Schulze; D Palli; M Crous-Bou; A Dorronsoro; K Overvad; A Barricarte Gurrea; G Severi; R C H Vermeulen; T M Sandanger; R C Travis; T Key; P Amiano; B Van Guelpen; M Johansson; M Sund; R Tumino; N Wareham; C Sacerdote; V Krogh; P Brennan; E Riboli; E Weiderpass; M J Gunter; V Chajès

doi:10.1186/s12885-023-10611-0

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

S G Yammine^*
, I Huybrechts
, C Biessy
, L Dossus
, S Panico
, M J Sánchez
, V Benetou
, R Turzanski-Fortner
, V Katzke
, A Idahl
, G Skeie
, K Standahl Olsen
, A Tjønneland
, J Halkjaer
, S Colorado-Yohar
, A K Heath
, E Sonestedt
, H Sartor
, M B Schulze
, D Palli

M Crous-Bou, A Dorronsoro, K Overvad, A Barricarte Gurrea, G Severi, R C H Vermeulen, T M Sandanger, R C Travis, T Key, P Amiano, B Van Guelpen, M Johansson, M Sund, R Tumino, N Wareham, C Sacerdote, V Krogh, P Brennan, E Riboli, E Weiderpass, M J Gunter, V Chajès

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.

RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile Q5-Q1=0.77, 95% CI = 0.64; 0.92, p trend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HR per unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HR per unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HR per unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.

CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Original language	English
Article number	159
Pages (from-to)	1-12
Journal	BMC Cancer
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12885-023-10611-0
Publication status	Published - 16 Feb 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

Funding

The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition PotsdamRehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (C864/A 14136 to EPIC-Norfolk (DOI https://doi.org/10.22025/2019.10.105.00004 ); C8221/A29017 to EPIC-Oxford), Medical Research Council (MR/N003284/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford). (United Kingdom). We would like to thank ‘the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands’ for their contribution and ongoing support to the EPIC Study. This work was undertaken during the tenure of a doctoral Fellowship supported by INCa (INCa 2016 − 184), by Fondation ARC pour la recherche sur le cancer (ARC 2019-DOC4) and by IARC.

Funders	Funder number
Catalan Institute of Oncology - ICO
Compagnia di SanPaolo
County Councils of Skåne
Department of Epidemiology and Biostatistics
Dutch Prevention Funds
Dutch ZON (Zorg Onderzoek Nederland
FIS
German Institute of Human Nutrition PotsdamRehbruecke
Health Research Fund
LK Research Funds
NKR
National Institute for Public Health and the Environment
Netherlands Cancer Registry
Kræftens Bekæmpelse
Deutsches Krebsforschungszentrum
Centre International de Recherche sur le Cancer
National Research Council
University of Maryland School of Public Health
Cancer Research UK
World Cancer Research Fund
Imperial College London
Institut national de la santé et de la recherche médicale
Bundesministerium für Bildung und Forschung
Cancerfonden
Ministerie van Volksgezondheid, Welzijn en Sport
Fondation ARC pour la Recherche sur le Cancer	ARC 2019-DOC4
Ligue Contre le Cancer
Vetenskapsrådet
Instituto de Salud Carlos III
Associazione Italiana per la Ricerca sul Cancro
Deutsche Krebshilfe
Rijksinstituut voor Volksgezondheid en Milieu
Institut Gustave-Roussy
Mutuelle Générale de l'Education Nationale
Consejería de Salud y Familias, Junta de Andalucía
NIHR Imperial Biomedical Research Centre

Keywords

Diet
Endometrial cancer
Epidemiology
Fatty acids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Yammine, S. G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M. J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, A., Skeie, G., Olsen, K. S., Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A. K., Sonestedt, E., Sartor, H., Schulze, M. B., ... Chajès, V. (2023). Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer, 23(1), 1-12. Article 159. https://doi.org/10.1186/s12885-023-10611-0

@article{ab69d7d1775a4cd5a4a28713e87fe159,

title = "Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition",

abstract = "BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95\% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile Q5-Q1=0.77, 95\% CI = 0.64; 0.92, p trend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HR per unit increment=0.94, 95\%CI= (0.90;0.98), p = 0.01) but not from animal sources (HR per unit increment= 1.00, 95\%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HR per unit increment= 0.93, 95\%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.",

keywords = "Diet, Endometrial cancer, Epidemiology, Fatty acids",

author = "Yammine, \{S G\} and I Huybrechts and C Biessy and L Dossus and S Panico and S{\'a}nchez, \{M J\} and V Benetou and R Turzanski-Fortner and V Katzke and A Idahl and G Skeie and Olsen, \{K Standahl\} and A Tj{\o}nneland and J Halkjaer and S Colorado-Yohar and Heath, \{A K\} and E Sonestedt and H Sartor and Schulze, \{M B\} and D Palli and M Crous-Bou and A Dorronsoro and K Overvad and Gurrea, \{A Barricarte\} and G Severi and Vermeulen, \{R C H\} and Sandanger, \{T M\} and Travis, \{R C\} and T Key and P Amiano and \{Van Guelpen\}, B and M Johansson and M Sund and R Tumino and N Wareham and C Sacerdote and V Krogh and P Brennan and E Riboli and E Weiderpass and Gunter, \{M J\} and V Chaj{\`e}s",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = feb,

day = "16",

doi = "10.1186/s12885-023-10611-0",

language = "English",

volume = "23",

pages = "1--12",

journal = "BMC Cancer",

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Yammine, SG, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, MJ, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, KS, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, AK, Sonestedt, E, Sartor, H, Schulze, MB, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, AB, Severi, G, Vermeulen, RCH, Sandanger, TM, Travis, RC, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, MJ & Chajès, V 2023, 'Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition', BMC Cancer, vol. 23, no. 1, 159, pp. 1-12. https://doi.org/10.1186/s12885-023-10611-0

TY - JOUR

T1 - Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

AU - Yammine, S G

AU - Huybrechts, I

AU - Biessy, C

AU - Dossus, L

AU - Panico, S

AU - Sánchez, M J

AU - Benetou, V

AU - Turzanski-Fortner, R

AU - Katzke, V

AU - Idahl, A

AU - Skeie, G

AU - Olsen, K Standahl

AU - Tjønneland, A

AU - Halkjaer, J

AU - Colorado-Yohar, S

AU - Heath, A K

AU - Sonestedt, E

AU - Sartor, H

AU - Schulze, M B

AU - Palli, D

AU - Crous-Bou, M

AU - Dorronsoro, A

AU - Overvad, K

AU - Gurrea, A Barricarte

AU - Severi, G

AU - Vermeulen, R C H

AU - Sandanger, T M

AU - Travis, R C

AU - Key, T

AU - Amiano, P

AU - Van Guelpen, B

AU - Johansson, M

AU - Sund, M

AU - Tumino, R

AU - Wareham, N

AU - Sacerdote, C

AU - Krogh, V

AU - Brennan, P

AU - Riboli, E

AU - Weiderpass, E

AU - Gunter, M J

AU - Chajès, V

PY - 2023/2/16

Y1 - 2023/2/16

N2 - BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile Q5-Q1=0.77, 95% CI = 0.64; 0.92, p trend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HR per unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HR per unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HR per unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

AB - BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile Q5-Q1=0.77, 95% CI = 0.64; 0.92, p trend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HR per unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HR per unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HR per unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

KW - Diet

KW - Endometrial cancer

KW - Epidemiology

KW - Fatty acids

UR - https://www.scopus.com/pages/publications/85148260026

U2 - 10.1186/s12885-023-10611-0

DO - 10.1186/s12885-023-10611-0

M3 - Article

C2 - 36797668

SN - 1471-2407

VL - 23

SP - 1

EP - 12

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 159

ER -

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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