Dexamethasone nanomedicines for COVID-19

Twan Lammers; Alexandros Marios Sofias; Roy van der Meel; Raymond Schiffelers; Gert Storm; Frank Tacke; Steffen Koschmieder; Tim H Brümmendorf; Fabian Kiessling; Josbert M Metselaar

doi:10.1038/s41565-020-0752-z

Dexamethasone nanomedicines for COVID-19

Twan Lammers, Alexandros Marios Sofias, Roy van der Meel, Raymond Schiffelers, Gert Storm, Frank Tacke, Steffen Koschmieder, Tim H Brümmendorf, Fabian Kiessling, Josbert M Metselaar

Department of Hepatology and Gastroenterology, Charité University Medicine, Berlin, Germany.
Department of Medicine IV (Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation), RWTH Aachen University, Aachen, Germany.
Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	Nature Nanotechnology
Volume	15
Issue number	8
DOIs	https://doi.org/10.1038/s41565-020-0752-z
Publication status	Published - Aug 2020

Keywords

Betacoronavirus/drug effects
COVID-19
Coronavirus Infections/drug therapy
Dexamethasone/therapeutic use
Humans
Nanomedicine
Pandemics
Pneumonia, Viral/drug therapy
SARS-CoV-2

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10.1038/s41565-020-0752-z

s41565-020-0752-zFinal published version, 5.28 MBLicence: Taverne

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AU - Sofias, Alexandros Marios

AU - van der Meel, Roy

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AU - Storm, Gert

AU - Tacke, Frank

AU - Koschmieder, Steffen

AU - Brümmendorf, Tim H

AU - Kiessling, Fabian

AU - Metselaar, Josbert M

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KW - COVID-19

KW - Coronavirus Infections/drug therapy

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KW - Nanomedicine

KW - Pandemics

KW - Pneumonia, Viral/drug therapy

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Dexamethasone nanomedicines for COVID-19

Abstract

Keywords

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