Abstract
Endothelial cells play a pathological role in cancer and chronic inflammation and are therefore attractive targets for therapeutic intervention. This review focuses on endothelial cell specific drug targeting strategies for the treatment of these diseases. The cellular and molecular processes involved in the activation of endothelial cells in angiogenesis and inflammation will be reviewed. Various target epitopes expressed by activated endothelium suitable for targeting purposes, design and development of drug-carrier complexes, drugs of interest which might interfere with endothelial cell activation, as well as in vitro and in vivo experimental approaches to study (intra)cellular drug delivery will be discussed. © 2002 Elsevier Science B.V. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 133-165 |
| Journal | Biotechnolology Annual Review |
| Volume | 8 |
| DOIs | |
| Publication status | Published - 11 Jan 2002 |
Keywords
- αvβ3 integrin
- Angiogenesis
- Angiogenesis models
- Angiopoietins
- Anti-angiogenic drugs
- Anti-inflammatory drugs
- Cancer
- Cell adhesion molecules
- Chronic inflammation
- Cytokines
- Drug carriers
- Drug-carrier complex
- FGF
- angiopoietin receptor
- drug carrier
- epitope
- fibroblast growth factor receptor
- vasculotropin receptor
- vitronectin receptor
- angiogenesis
- arthritis
- atherosclerosis
- cancer therapy
- cell activation
- chronic inflammation
- drug targeting
- endothelium cell
- enteritis
- in vitro study
- in vivo study
- inflammatory disease
- review
- signal transduction
