Abstract
Additive manufacturing forms a potential route towards economically viable production of cellular constructs for tissue engineering. Hydrogels are a suitable class of materials for cell delivery and 3D culture, but are generally unsuitable as construction materials. Gelatine-methacrylamide is an example of such a hydrogel system widely used in the field of tissue engineering, e.g. for cartilage and cardiovascular applications. Here we show that by the addition of gellan gum to gelatine-methacrylamide and tailoring salt concentrations, rheological properties such as pseudo-plasticity and yield stress can be optimised towards gel dispensing for additive manufacturing processes. In the hydrogel formulation, salt is partly substituted by mannose to obtain isotonicity and prevent a reduction in cell viability. With this, the potential of this new bioink for additive tissue manufacturing purposes is demonstrated. This journal is © the Partner Organisations 2014.
Original language | English |
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Pages (from-to) | 2282-2289 |
Journal | Journal of Materials Chemistry A |
Volume | 2 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- gellan gum
- hydrogel
- 3d printing