Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

Rachel S Kelly; Sandrine Roulland; Ester Morgado; Stéphanie Sungalee; Nathalie Jouve; Rosario Tumino; Vittorio Krogh; Salvatore Panico; Silvia Polidoro; Giovanna Masala; María-José Sánchez; Maria-Dolores Chirlaque; Núria Sala; Aurelio Barricarte Gurrea; Miren Dorronsoro; Ruth C Travis; Elio Riboli; Marc Gunter; Neil Murphy; Roel Vermeulen; H B Bueno-de-Mesquita; Petra H Peeters; Antonia Trichopoulou; Dimitrios Trichopoulos; Pagona Lagiou; Alexandra Nieters; Federico Canzian; Rudolf Kaaks; Heiner Boeing; Elisabete Weiderpass; Tanja Stocks; Beatrice Melin; Kim Overvad; Anne Tjønneland; Anja Olsen; Paul Brennan; Mattias Johansson; Bertrand Nadel; Paolo Vineis

doi:10.1007/s10552-015-0677-2

Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

Rachel S Kelly, Sandrine Roulland, Ester Morgado, Stéphanie Sungalee, Nathalie Jouve, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Silvia Polidoro, Giovanna Masala, María-José Sánchez, Maria-Dolores Chirlaque, Núria Sala, Aurelio Barricarte Gurrea, Miren Dorronsoro, Ruth C Travis, Elio Riboli, Marc Gunter, Neil Murphy, Roel VermeulenH B Bueno-de-Mesquita, Petra H Peeters, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, Alexandra Nieters, Federico Canzian, Rudolf Kaaks, Heiner Boeing, Elisabete Weiderpass, Tanja Stocks, Beatrice Melin, Kim Overvad, Anne Tjønneland, Anja Olsen, Paul Brennan, Mattias Johansson, Bertrand Nadel, Paolo Vineis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.

METHODS: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case-control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)(+) as compared to t(14;18)(-) cases.

RESULTS: Among incident FL cases, educational level (χ (2) p = 0.021) and height (χ (2) p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)(HF)] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)(+) FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)(-) cases.

CONCLUSIONS: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.

Original language	English
Pages (from-to)	1845-1855
Journal	Cancer Causes & Control
Volume	26
Issue number	12
DOIs	https://doi.org/10.1007/s10552-015-0677-2
Publication status	Published - 30 Sept 2015

Keywords

Follicular lymphoma
Translocation
t(14;18)
Height

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Kelly, R. S., Roulland, S., Morgado, E., Sungalee, S., Jouve, N., Tumino, R., Krogh, V., Panico, S., Polidoro, S., Masala, G., Sánchez, M.-J., Chirlaque, M.-D., Sala, N., Gurrea, A. B., Dorronsoro, M., Travis, R. C., Riboli, E., Gunter, M., Murphy, N., ... Vineis, P. (2015). Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma. Cancer Causes & Control, 26(12), 1845-1855. https://doi.org/10.1007/s10552-015-0677-2

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title = "Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma",

abstract = "PURPOSE: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.METHODS: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case-control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)(+) as compared to t(14;18)(-) cases.RESULTS: Among incident FL cases, educational level (χ (2) p = 0.021) and height (χ (2) p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)(HF)] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)(+) FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)(-) cases.CONCLUSIONS: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.",

keywords = "Follicular lymphoma, Translocation, t(14;18), Height",

author = "Kelly, {Rachel S} and Sandrine Roulland and Ester Morgado and St{\'e}phanie Sungalee and Nathalie Jouve and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Silvia Polidoro and Giovanna Masala and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Maria-Dolores Chirlaque and N{\'u}ria Sala and Gurrea, {Aurelio Barricarte} and Miren Dorronsoro and Travis, {Ruth C} and Elio Riboli and Marc Gunter and Neil Murphy and Roel Vermeulen and Bueno-de-Mesquita, {H B} and Peeters, {Petra H} and Antonia Trichopoulou and Dimitrios Trichopoulos and Pagona Lagiou and Alexandra Nieters and Federico Canzian and Rudolf Kaaks and Heiner Boeing and Elisabete Weiderpass and Tanja Stocks and Beatrice Melin and Kim Overvad and Anne Tj{\o}nneland and Anja Olsen and Paul Brennan and Mattias Johansson and Bertrand Nadel and Paolo Vineis",

year = "2015",

month = sep,

day = "30",

doi = "10.1007/s10552-015-0677-2",

language = "English",

volume = "26",

pages = "1845--1855",

journal = "Cancer Causes & Control",

issn = "0957-5243",

publisher = "Springer",

number = "12",

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Kelly, RS, Roulland, S, Morgado, E, Sungalee, S, Jouve, N, Tumino, R, Krogh, V, Panico, S, Polidoro, S, Masala, G, Sánchez, M-J, Chirlaque, M-D, Sala, N, Gurrea, AB, Dorronsoro, M, Travis, RC, Riboli, E, Gunter, M, Murphy, N, Vermeulen, R, Bueno-de-Mesquita, HB, Peeters, PH, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Nieters, A, Canzian, F, Kaaks, R, Boeing, H, Weiderpass, E, Stocks, T, Melin, B, Overvad, K, Tjønneland, A, Olsen, A, Brennan, P, Johansson, M, Nadel, B & Vineis, P 2015, 'Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma', Cancer Causes & Control, vol. 26, no. 12, pp. 1845-1855. https://doi.org/10.1007/s10552-015-0677-2

TY - JOUR

T1 - Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

AU - Kelly, Rachel S

AU - Roulland, Sandrine

AU - Morgado, Ester

AU - Sungalee, Stéphanie

AU - Jouve, Nathalie

AU - Tumino, Rosario

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Polidoro, Silvia

AU - Masala, Giovanna

AU - Sánchez, María-José

AU - Chirlaque, Maria-Dolores

AU - Sala, Núria

AU - Gurrea, Aurelio Barricarte

AU - Dorronsoro, Miren

AU - Travis, Ruth C

AU - Riboli, Elio

AU - Gunter, Marc

AU - Murphy, Neil

AU - Vermeulen, Roel

AU - Bueno-de-Mesquita, H B

AU - Peeters, Petra H

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Lagiou, Pagona

AU - Nieters, Alexandra

AU - Canzian, Federico

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Weiderpass, Elisabete

AU - Stocks, Tanja

AU - Melin, Beatrice

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Brennan, Paul

AU - Johansson, Mattias

AU - Nadel, Bertrand

AU - Vineis, Paolo

PY - 2015/9/30

Y1 - 2015/9/30

N2 - PURPOSE: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.METHODS: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case-control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)(+) as compared to t(14;18)(-) cases.RESULTS: Among incident FL cases, educational level (χ (2) p = 0.021) and height (χ (2) p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)(HF)] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)(+) FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)(-) cases.CONCLUSIONS: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.

AB - PURPOSE: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.METHODS: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case-control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)(+) as compared to t(14;18)(-) cases.RESULTS: Among incident FL cases, educational level (χ (2) p = 0.021) and height (χ (2) p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)(HF)] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)(+) FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)(-) cases.CONCLUSIONS: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.

KW - Follicular lymphoma

KW - Translocation

KW - t(14;18)

KW - Height

U2 - 10.1007/s10552-015-0677-2

DO - 10.1007/s10552-015-0677-2

M3 - Article

C2 - 26424368

SN - 0957-5243

VL - 26

SP - 1845

EP - 1855

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 12

ER -

Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

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Keywords

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