Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles

Xinyue Wang; Huaiyong Chen; Fabrizio Chiodo; B. Tefsen

Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles

Xinyue Wang, Huaiyong Chen, Fabrizio Chiodo^*, B. Tefsen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Manyinfectiousdiseaseslackcheap, fast,andreliableserodiagnostictools. Recently, glycanscoupledtogoldnanoparticles(GNPs)haveshownpotentialtofillthisvoidby utilizingthemasacoatinginELISAexperiments. Inthisstudy,weusedGNPsfunctionalizedeitherwithgalactofuranose(Galf), rhamnose(Rhap)oramixtureof these monosaccharidestodetectthepresenceofIgMandIgGantibodiesagainstthesenonhumancarbohydratesinseraobtainedfromtuberculosispatientsandcontrolgroups. Ourfindingsconfirmthewideabundanceofanti-Rhapantibodiesinhumansandshow forthefirsttimethepresenceofanti-Galf antibodiesinhumansera.ThisstudysupportsfurtherinvestigationofusingGNP-ELISAwithmicrobe-specificcarbohydratesfor serodiagnosisofinfectiousdiseases.

Original language	English
Journal	Matters
Publication status	Published - 30 Aug 2019
Externally published	Yes

Keywords

galactofuranose
rhamnose
gold nanoparticle
tuberculosis
serodiagnostic assay

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles",

abstract = "Manyinfectiousdiseaseslackcheap, fast,andreliableserodiagnostictools. Recently, glycanscoupledtogoldnanoparticles(GNPs)haveshownpotentialtofillthisvoidby utilizingthemasacoatinginELISAexperiments. Inthisstudy,weusedGNPsfunctionalizedeitherwithgalactofuranose(Galf), rhamnose(Rhap)oramixtureof these monosaccharidestodetectthepresenceofIgMandIgGantibodiesagainstthesenonhumancarbohydratesinseraobtainedfromtuberculosispatientsandcontrolgroups. Ourfindingsconfirmthewideabundanceofanti-Rhapantibodiesinhumansandshow forthefirsttimethepresenceofanti-Galf antibodiesinhumansera.ThisstudysupportsfurtherinvestigationofusingGNP-ELISAwithmicrobe-specificcarbohydratesfor serodiagnosisofinfectiousdiseases.",

keywords = "galactofuranose, rhamnose, gold nanoparticle, tuberculosis, serodiagnostic assay",

author = "Xinyue Wang and Huaiyong Chen and Fabrizio Chiodo and B. Tefsen",

year = "2019",

month = aug,

day = "30",

language = "English",

journal = "Matters",

}

TY - JOUR

T1 - Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles

AU - Wang, Xinyue

AU - Chen, Huaiyong

AU - Chiodo, Fabrizio

AU - Tefsen, B.

PY - 2019/8/30

Y1 - 2019/8/30

N2 - Manyinfectiousdiseaseslackcheap, fast,andreliableserodiagnostictools. Recently, glycanscoupledtogoldnanoparticles(GNPs)haveshownpotentialtofillthisvoidby utilizingthemasacoatinginELISAexperiments. Inthisstudy,weusedGNPsfunctionalizedeitherwithgalactofuranose(Galf), rhamnose(Rhap)oramixtureof these monosaccharidestodetectthepresenceofIgMandIgGantibodiesagainstthesenonhumancarbohydratesinseraobtainedfromtuberculosispatientsandcontrolgroups. Ourfindingsconfirmthewideabundanceofanti-Rhapantibodiesinhumansandshow forthefirsttimethepresenceofanti-Galf antibodiesinhumansera.ThisstudysupportsfurtherinvestigationofusingGNP-ELISAwithmicrobe-specificcarbohydratesfor serodiagnosisofinfectiousdiseases.

AB - Manyinfectiousdiseaseslackcheap, fast,andreliableserodiagnostictools. Recently, glycanscoupledtogoldnanoparticles(GNPs)haveshownpotentialtofillthisvoidby utilizingthemasacoatinginELISAexperiments. Inthisstudy,weusedGNPsfunctionalizedeitherwithgalactofuranose(Galf), rhamnose(Rhap)oramixtureof these monosaccharidestodetectthepresenceofIgMandIgGantibodiesagainstthesenonhumancarbohydratesinseraobtainedfromtuberculosispatientsandcontrolgroups. Ourfindingsconfirmthewideabundanceofanti-Rhapantibodiesinhumansandshow forthefirsttimethepresenceofanti-Galf antibodiesinhumansera.ThisstudysupportsfurtherinvestigationofusingGNP-ELISAwithmicrobe-specificcarbohydratesfor serodiagnosisofinfectiousdiseases.

KW - galactofuranose

KW - rhamnose

KW - gold nanoparticle

KW - tuberculosis

KW - serodiagnostic assay

M3 - Article

JO - Matters

JF - Matters

ER -

Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rhamnose-coated gold nanoparticles

Abstract

Keywords

UN SDGs

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