Detection of four human milk groups with respect to lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis

B. Stahl*, S. Thurl, J. Henker, M. Siegel, B. Finke, G. Sawatzki

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Oligosaccharides from human milk samples obtained from individual donors were analyzed using high-pH anion-exchange chromatography. Three patterns of neutral oligosaccharides were detected corresponding to milk groups already described. These oligosaccharide groups correspond to the Lewis blood types Lea-b+, Lea+b-, and Lea-b-. A new carbohydrate pattern was detected in a milk sample from a Lea-b- person in which only nonfucosylated oligosaccharides and compounds bearing α1, 3-linked fucosyl residues were found. This finding led to the hypothesis that there exist 4 different oligosaccharide milk groups that fit well to the genetic basis of the Lewis blood group system.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume501
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'Detection of four human milk groups with respect to lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis'. Together they form a unique fingerprint.

Cite this