Design and Development of Divalent Lectin Ligands

Roland Pieters

doi:10.1016/B978-0-12-819475-1.00088-2

Design and Development of Divalent Lectin Ligands

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Interference with protein carbohydrate interactions can potentially lead to many new therapeutics. However, challenges need to be overcome, one of which is weak affinity of glycoligands for their targets. Multivalent ligands can bind much more potent. Here we describe the road traveled toward potent divalent ligands for the Pseudomonas aeruginosa lectin LecA taking advantage of the most straightforward multivalency mechanism: chelation. Aspects of flexibility versus rigidity, thermodynamic parameters and molecular design are discussed.

Original language	English
Title of host publication	Comprehensive Glycoscience
Editors	Joseph J. Barchi, Jr.
Publisher	Elsevier
Chapter	3.17
Pages	405-413
Number of pages	9
Volume	3
Edition	2
ISBN (Print)	978-0-12-822244-7
DOIs	https://doi.org/10.1016/B978-0-12-819475-1.00088-2
Publication status	Published - 24 Jun 2021

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10.1016/B978-0-12-819475-1.00088-2

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Design and Development of Divalent Lectin Ligands

Abstract

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