Depression's Next Top Model: Pharmacology of olfactory bulbectomy-induced behaviors

M.E. Breuer

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

The aim of this thesis is to provide a better overview of the olfactory bulbectomy model, with regards to its validity as a model for depression, as well as to give further insight to the possible working mechanisms of known and new antidepressants. This thesis also aims to explore the effects of long- and short-term antidepressant treatment, and how treatment duration and the dose of drug used may lead to different effects after cessation of treatment. Finally, the effects of putative new antidepressants on bulbectomy-induced hyperactivity will be examined, taking us a step closer to finding possible new treatments for this debilitating disease.
Original languageUndefined/Unknown
QualificationDoctor of Philosophy
Awarding Institution
  • Utrecht University
Supervisors/Advisors
  • Olivier, B., Primary supervisor
  • Groenink, Lucianne, Co-supervisor
  • Oosting, R.S., Co-supervisor
Award date4 Feb 2009
Publisher
Print ISBNs978-90-39349823
Publication statusPublished - 4 Feb 2009

Keywords

  • Psychopharmacology
  • Farmacie/Biofarmaceutische wetenschappen (FARM)
  • Farmacie(FARM)
  • Biomedische technologie en medicijnen
  • Pharmacology
  • Drugmisbruik en verslaving

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