Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Marina Boccardi; Martina Bocchetta; Liana G Apostolova; Josephine Barnes; George Bartzokis; Gabriele Corbetta; Charles DeCarli; Leyla deToledo-Morrell; Michael Firbank; Rossana Ganzola; Lotte Gerritsen; Wouter Henneman; Ronald J Killiany; Nikolai Malykhin; Patrizio Pasqualetti; Jens C Pruessner; Alberto Redolfi; Nicolas Robitaille; Hilkka Soininen; Daniele Tolomeo; Lei Wang; Craig Watson; Henrike Wolf; Henri Duvernoy; Simon Duchesne; Clifford R Jack; Giovanni B Frisoni; EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation

doi:10.1016/j.jalz.2014.02.009

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Marina Boccardi
, Martina Bocchetta
, Liana G Apostolova
, Josephine Barnes
, George Bartzokis
, Gabriele Corbetta
, Charles DeCarli
, Leyla deToledo-Morrell
, Michael Firbank
, Rossana Ganzola
, Lotte Gerritsen
, Wouter Henneman
, Ronald J Killiany
, Nikolai Malykhin
, Patrizio Pasqualetti
, Jens C Pruessner
, Alberto Redolfi
, Nicolas Robitaille
, Hilkka Soininen
, Daniele Tolomeo

Lei Wang, Craig Watson, Henrike Wolf, Henri Duvernoy, Simon Duchesne, Clifford R Jack, Giovanni B Frisoni, EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation

LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy. Electronic address: [email protected].
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Laboratory of NeuroImaging, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy.
Department of Neurology, University of California, Davis, Davis, CA, USA.
Department of Neurological Sciences, Rush University, Chicago, IL, USA.
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
Department of Medical Epidemiology & Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Psychiatry, VU university Medical Center / GGZ inGeest, Amsterdam, the Netherlands.
Department of Radiology and Nuclear Medicine; Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands.
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Department of Biomedical Engineering, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
SeSMIT (Service for Medical Statistics and Information Technology) - AFaR (Fatebenefratelli Association for Research), Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy; Unit of Clinical and Molecular Epidemiology, IRCCS "San Raffaele Pisana", Rome, Italy.
Department of Psychiatry, McGill Centre for Studies in Aging, McGill University, Montreal, Quebec, Canada.
Department of Radiology, Université Laval and Centre de Recherche Université Laval - Robert Giffard, Quebec City, Quebec, Canada.
Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Neurology and the Department of Anatomy & Cell Biology, Wayne State University School of Medicine, D-University Health Center, St. Antoine, Detroit, MI, USA.
Department of Psychiatry Research and Geriatric Psychiatry, Psychiatric University Hospitals, University of Zurich, Zurich, Switzerland; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Chemin des Relançons, Besançon, France.
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy; Memory Clinic and LANVIE (Laboratory of Neuroimaging of Aging), University Hospitals and University of Geneva, Geneva, Switzerland.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.

METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.

RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.

DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

Original language	English
Pages (from-to)	126-38
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2014.02.009
Publication status	Published - Feb 2015
Externally published	Yes

Keywords

Alzheimer Disease
Atrophy
Consensus
Delphi Technique
Hippocampus
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Internationality
Magnetic Resonance Imaging
Neuroimaging
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.jalz.2014.02.009

Cite this

Boccardi, M., Bocchetta, M., Apostolova, L. G., Barnes, J., Bartzokis, G., Corbetta, G., DeCarli, C., deToledo-Morrell, L., Firbank, M., Ganzola, R., Gerritsen, L., Henneman, W., Killiany, R. J., Malykhin, N., Pasqualetti, P., Pruessner, J. C., Redolfi, A., Robitaille, N., Soininen, H., ... EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation (2015). Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. Alzheimer's and Dementia, 11(2), 126-38. https://doi.org/10.1016/j.jalz.2014.02.009

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title = "Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance",

abstract = "BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100\% of hippocampal tissue, 100\% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.",

keywords = "Alzheimer Disease, Atrophy, Consensus, Delphi Technique, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internationality, Magnetic Resonance Imaging, Neuroimaging, Journal Article, Research Support, Non-U.S. Gov't",

author = "Marina Boccardi and Martina Bocchetta and Apostolova, \{Liana G\} and Josephine Barnes and George Bartzokis and Gabriele Corbetta and Charles DeCarli and Leyla deToledo-Morrell and Michael Firbank and Rossana Ganzola and Lotte Gerritsen and Wouter Henneman and Killiany, \{Ronald J\} and Nikolai Malykhin and Patrizio Pasqualetti and Pruessner, \{Jens C\} and Alberto Redolfi and Nicolas Robitaille and Hilkka Soininen and Daniele Tolomeo and Lei Wang and Craig Watson and Henrike Wolf and Henri Duvernoy and Simon Duchesne and Jack, \{Clifford R\} and Frisoni, \{Giovanni B\} and \{EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation\}",

year = "2015",

month = feb,

doi = "10.1016/j.jalz.2014.02.009",

language = "English",

volume = "11",

pages = "126--38",

journal = "Alzheimer's and Dementia",

issn = "1552-5279",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Boccardi, M, Bocchetta, M, Apostolova, LG, Barnes, J, Bartzokis, G, Corbetta, G, DeCarli, C, deToledo-Morrell, L, Firbank, M, Ganzola, R, Gerritsen, L, Henneman, W, Killiany, RJ, Malykhin, N, Pasqualetti, P, Pruessner, JC, Redolfi, A, Robitaille, N, Soininen, H, Tolomeo, D, Wang, L, Watson, C, Wolf, H, Duvernoy, H, Duchesne, S, Jack, CR, Frisoni, GB & EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation 2015, 'Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance', Alzheimer's and Dementia, vol. 11, no. 2, pp. 126-38. https://doi.org/10.1016/j.jalz.2014.02.009

TY - JOUR

T1 - Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

AU - Boccardi, Marina

AU - Bocchetta, Martina

AU - Apostolova, Liana G

AU - Barnes, Josephine

AU - Bartzokis, George

AU - Corbetta, Gabriele

AU - DeCarli, Charles

AU - deToledo-Morrell, Leyla

AU - Firbank, Michael

AU - Ganzola, Rossana

AU - Gerritsen, Lotte

AU - Henneman, Wouter

AU - Killiany, Ronald J

AU - Malykhin, Nikolai

AU - Pasqualetti, Patrizio

AU - Pruessner, Jens C

AU - Redolfi, Alberto

AU - Robitaille, Nicolas

AU - Soininen, Hilkka

AU - Tolomeo, Daniele

AU - Wang, Lei

AU - Watson, Craig

AU - Wolf, Henrike

AU - Duvernoy, Henri

AU - Duchesne, Simon

AU - Jack, Clifford R

AU - Frisoni, Giovanni B

AU - EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

AB - BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

KW - Alzheimer Disease

KW - Atrophy

KW - Consensus

KW - Delphi Technique

KW - Hippocampus

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Internationality

KW - Magnetic Resonance Imaging

KW - Neuroimaging

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jalz.2014.02.009

DO - 10.1016/j.jalz.2014.02.009

M3 - Article

C2 - 25130658

SN - 1552-5279

VL - 11

SP - 126

EP - 138

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Abstract

Keywords

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