DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task

D. B. Spronk; C. P.M. Veth; M. Arns; P. R. Schofield; C. Dobson-Stone; J. G. Ramaekers; B. Franke; E. R.A. de Bruijn; R. J. Verkes

doi:10.1016/j.clinph.2012.11.008

DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task

D. B. Spronk^*, C. P.M. Veth, M. Arns, P. R. Schofield, C. Dobson-Stone, J. G. Ramaekers, B. Franke, E. R.A. de Bruijn, R. J. Verkes

^*Corresponding author for this work

Department of Psychiatry (966), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Research Institute Brainclinics, Nijmegen, the Netherlands
Neuroscience Research Australia, Sydney, Australia
School of Medical Sciences, University of New South Wales, Sydney, Australia
Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
Department of Human Genetics (855), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Department of Clinical, Health and Neuropsychology, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: The amplitude and latency of the P300 may be associated by variations in dopaminergic genes. The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and latency in an auditory oddball task. Methods: The P300 ERP was assessed by a two-tone auditory oddball paradigm in a large sample of 320 healthy volunteers. The Val108/158Met polymorphism (rs4680) of the COMT gene and the -1021C>T polymorphism (rs1611115) of the DBH gene were genotyped. P300 amplitude and latency were compared across genotype groups using analysis of variance. Results: There were no differences in demographic characteristics in subjects for genotypic subgroups. No genotype associations were observed for the P300 amplitude and latency on frontal, central and parietal electrode positions. Conclusions: COMT Val108/158Met and DBH -1021C>T polymorphisms do not show evidence of association with characteristics of the P300 ERP in an auditory oddball paradigm in healthy volunteers. Significance: We failed to find evidence for the association between dopaminergic enzymatic polymorphisms and the P300 ERP in healthy volunteers, in the largest study undertaken to date.

Original language	English
Pages (from-to)	909-915
Number of pages	7
Journal	Clinical Neurophysiology
Volume	124
Issue number	5
DOIs	https://doi.org/10.1016/j.clinph.2012.11.008
Publication status	Published - 1 May 2013

Funding

We acknowledge that data and support was provided by BRAINnet; www.BRAINnet.net, under the governance of the BRAINnet Foundation. BRAINnet is the scientific network that coordinates access to the Brain Resource International Database for independent scientific purposes. We express our gratitude to Michelle Wang and to Kylie Maidment for their cooperation. We furthermore like to thank the two anonymous reviewers for their helpful comments. The authors declare no conflict of interest.

Keywords

Brain Research and Integrative Neuroscience Network (BRAINnet)
COMT
DBH
Dopamine
Endophenotype
ERP
Genomics
P3
P300
Polymorphisms

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@article{ec002ae823cf4be78f8b899b43892701,

title = "DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task",

abstract = "Objective: The amplitude and latency of the P300 may be associated by variations in dopaminergic genes. The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and latency in an auditory oddball task. Methods: The P300 ERP was assessed by a two-tone auditory oddball paradigm in a large sample of 320 healthy volunteers. The Val108/158Met polymorphism (rs4680) of the COMT gene and the -1021C>T polymorphism (rs1611115) of the DBH gene were genotyped. P300 amplitude and latency were compared across genotype groups using analysis of variance. Results: There were no differences in demographic characteristics in subjects for genotypic subgroups. No genotype associations were observed for the P300 amplitude and latency on frontal, central and parietal electrode positions. Conclusions: COMT Val108/158Met and DBH -1021C>T polymorphisms do not show evidence of association with characteristics of the P300 ERP in an auditory oddball paradigm in healthy volunteers. Significance: We failed to find evidence for the association between dopaminergic enzymatic polymorphisms and the P300 ERP in healthy volunteers, in the largest study undertaken to date.",

keywords = "Brain Research and Integrative Neuroscience Network (BRAINnet), COMT, DBH, Dopamine, Endophenotype, ERP, Genomics, P3, P300, Polymorphisms",

author = "Spronk, \{D. B.\} and Veth, \{C. P.M.\} and M. Arns and Schofield, \{P. R.\} and C. Dobson-Stone and Ramaekers, \{J. G.\} and B. Franke and \{de Bruijn\}, \{E. R.A.\} and Verkes, \{R. J.\}",

year = "2013",

month = may,

day = "1",

doi = "10.1016/j.clinph.2012.11.008",

language = "English",

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journal = "Clinical Neurophysiology",

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T1 - DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task

AU - Spronk, D. B.

AU - Veth, C. P.M.

AU - Arns, M.

AU - Schofield, P. R.

AU - Dobson-Stone, C.

AU - Ramaekers, J. G.

AU - Franke, B.

AU - de Bruijn, E. R.A.

AU - Verkes, R. J.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Objective: The amplitude and latency of the P300 may be associated by variations in dopaminergic genes. The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and latency in an auditory oddball task. Methods: The P300 ERP was assessed by a two-tone auditory oddball paradigm in a large sample of 320 healthy volunteers. The Val108/158Met polymorphism (rs4680) of the COMT gene and the -1021C>T polymorphism (rs1611115) of the DBH gene were genotyped. P300 amplitude and latency were compared across genotype groups using analysis of variance. Results: There were no differences in demographic characteristics in subjects for genotypic subgroups. No genotype associations were observed for the P300 amplitude and latency on frontal, central and parietal electrode positions. Conclusions: COMT Val108/158Met and DBH -1021C>T polymorphisms do not show evidence of association with characteristics of the P300 ERP in an auditory oddball paradigm in healthy volunteers. Significance: We failed to find evidence for the association between dopaminergic enzymatic polymorphisms and the P300 ERP in healthy volunteers, in the largest study undertaken to date.

AB - Objective: The amplitude and latency of the P300 may be associated by variations in dopaminergic genes. The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and latency in an auditory oddball task. Methods: The P300 ERP was assessed by a two-tone auditory oddball paradigm in a large sample of 320 healthy volunteers. The Val108/158Met polymorphism (rs4680) of the COMT gene and the -1021C>T polymorphism (rs1611115) of the DBH gene were genotyped. P300 amplitude and latency were compared across genotype groups using analysis of variance. Results: There were no differences in demographic characteristics in subjects for genotypic subgroups. No genotype associations were observed for the P300 amplitude and latency on frontal, central and parietal electrode positions. Conclusions: COMT Val108/158Met and DBH -1021C>T polymorphisms do not show evidence of association with characteristics of the P300 ERP in an auditory oddball paradigm in healthy volunteers. Significance: We failed to find evidence for the association between dopaminergic enzymatic polymorphisms and the P300 ERP in healthy volunteers, in the largest study undertaken to date.

KW - Brain Research and Integrative Neuroscience Network (BRAINnet)

KW - COMT

KW - DBH

KW - Dopamine

KW - Endophenotype

KW - ERP

KW - Genomics

KW - P3

KW - P300

KW - Polymorphisms

UR - https://www.scopus.com/pages/publications/84876154402

U2 - 10.1016/j.clinph.2012.11.008

DO - 10.1016/j.clinph.2012.11.008

M3 - Article

C2 - 23261162

AN - SCOPUS:84876154402

SN - 1388-2457

VL - 124

SP - 909

EP - 915

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 5

ER -

DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task

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Keywords

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