Abstract
Advances in biophysics and biochemistry have pushed back the limits of structural characterization of biomolecular assemblies. Mixing even a limited amount of experimental and/or bioinformatic data with modelling methods such as macromolecular docking represents a valuable strategy to predict 3D structures of complexes. In this chapter, we discuss and illustrate the various sources of data that can be used for this purpose, with emphasis on their combination with docking methods. Finally, we discuss the place of data-driven docking in the modelling of the 3D structures of biomolecular assemblies.
| Original language | English |
|---|---|
| Title of host publication | Protein-Protein Complexes |
| Subtitle of host publication | Analysis, Modeling and Drug Design |
| Editors | Martin Zacharias |
| Publisher | Imperial College Press |
| Pages | 182-208 |
| Number of pages | 27 |
| ISBN (Electronic) | 9781848163409 |
| ISBN (Print) | 9781848163386 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
Bibliographical note
Publisher Copyright:© 2010 by Imperial College Press. All rights reserved.