Cyprinid Herpesvirus 3: An Archetype of Fish Alloherpesviruses

Maxime Boutier, Maygane Ronsmans, Krzysztof Rakus, Joanna Jazowiecka-Rakus, Catherine Vancsok, Léa Morvan, Ma Michelle D Peñaranda, David M Stone, Keith Way, Steven J van Beurden, Andrew J Davison, Alain Vanderplasschen

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The order Herpesvirales encompasses viruses that share structural, genetic, and biological properties. However, members of this order infect hosts ranging from molluscs to humans. It is currently divided into three phylogenetically related families. The Alloherpesviridae family contains viruses infecting fish and amphibians. There are 12 alloherpesviruses described to date, 10 of which infect fish. Over the last decade, cyprinid herpesvirus 3 (CyHV-3) infecting common and koi carp has emerged as the archetype of fish alloherpesviruses. Since its first description in the late 1990s, this virus has induced important economic losses in common and koi carp worldwide. It has also had negative environmental implications by affecting wild carp populations. These negative impacts and the importance of the host species have stimulated studies aimed at developing diagnostic and prophylactic tools. Unexpectedly, the data generated by these applied studies have stimulated interest in CyHV-3 as a model for fundamental research. This review intends to provide a complete overview of the knowledge currently available on CyHV-3.

    Original languageEnglish
    Pages (from-to)161-256
    Number of pages96
    JournalAdvances in Virus Research
    Volume93
    DOIs
    Publication statusPublished - 2015

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    © 2015 Elsevier Inc. All rights reserved.

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