Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics

Jinqiang Zhang; Johan Kemmink; Dirk T. S. Rijkers; Rob M. J. Liskamp

doi:10.1021/ol201184b

Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics

Jinqiang Zhang, Johan Kemmink, Dirk T. S. Rijkers, Rob M. J. Liskamp

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted "click" cyclization. © 2011 American Chemical Society.

Original language	English
Pages (from-to)	3438-3441
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	13
DOIs	https://doi.org/10.1021/ol201184b
Publication status	Published - 1 Jul 2011

Keywords

copper
drug derivative
peptide
ruthenium
vancomycin
article
catalysis
chemical structure
chemistry
cyclization
synthesis

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10.1021/ol201184b

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abstract = "Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted {"}click{"} cyclization. {\textcopyright} 2011 American Chemical Society.",

keywords = "copper, drug derivative, peptide, ruthenium, vancomycin, article, catalysis, chemical structure, chemistry, cyclization, synthesis",

author = "Jinqiang Zhang and Johan Kemmink and Rijkers, \{Dirk T. S.\} and Liskamp, \{Rob M. J.\}",

year = "2011",

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doi = "10.1021/ol201184b",

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AU - Zhang, Jinqiang

AU - Kemmink, Johan

AU - Rijkers, Dirk T. S.

AU - Liskamp, Rob M. J.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted "click" cyclization. © 2011 American Chemical Society.

AB - Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted "click" cyclization. © 2011 American Chemical Society.

KW - copper

KW - drug derivative

KW - peptide

KW - ruthenium

KW - vancomycin

KW - article

KW - catalysis

KW - chemical structure

KW - chemistry

KW - cyclization

KW - synthesis

U2 - 10.1021/ol201184b

DO - 10.1021/ol201184b

M3 - Article

SN - 1523-7060

VL - 13

SP - 3438

EP - 3441

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics

Abstract

Keywords

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