Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine

Sara Galac

doi:10.1016/j.mce.2015.06.026

Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Spontaneous cortisol-secreting adrenocortical tumours in pet dogs are an attractive animal model for their human counterparts. Adrenal morphology and function are similar in dogs and humans, and adrenocortical tumours have comparable clinical and pathological characteristics. Their relatively high incidence in pet dogs represents a potential source of adrenocortical tumour tissue to facilitate research. The molecular characteristics of canine cortisol-secreting adrenocortical tumours suggest that they will be useful for the study of angiogenesis, the cAMP/protein kinase A pathway, and the role of Steroidogenic Factor-1 in adrenal tumourigenesis. Pet dogs with spontaneous cortisol-secreting adrenocortical tumours may also be useful in clinical testing of new drugs and in investigating the molecular background of adrenocortical tumours.

Original language	English
Pages (from-to)	34-39
Number of pages	6
Journal	Molecular and Cellular Endocrinology
DOIs	https://doi.org/10.1016/j.mce.2015.06.026
Publication status	Published - 27 Jun 2015

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10.1016/j.mce.2015.06.026

1-s2.0-S0303720715003330-mainFinal published version, 1.6 MBLicence: Taverne

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title = "Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine",

abstract = "Spontaneous cortisol-secreting adrenocortical tumours in pet dogs are an attractive animal model for their human counterparts. Adrenal morphology and function are similar in dogs and humans, and adrenocortical tumours have comparable clinical and pathological characteristics. Their relatively high incidence in pet dogs represents a potential source of adrenocortical tumour tissue to facilitate research. The molecular characteristics of canine cortisol-secreting adrenocortical tumours suggest that they will be useful for the study of angiogenesis, the cAMP/protein kinase A pathway, and the role of Steroidogenic Factor-1 in adrenal tumourigenesis. Pet dogs with spontaneous cortisol-secreting adrenocortical tumours may also be useful in clinical testing of new drugs and in investigating the molecular background of adrenocortical tumours.",

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AB - Spontaneous cortisol-secreting adrenocortical tumours in pet dogs are an attractive animal model for their human counterparts. Adrenal morphology and function are similar in dogs and humans, and adrenocortical tumours have comparable clinical and pathological characteristics. Their relatively high incidence in pet dogs represents a potential source of adrenocortical tumour tissue to facilitate research. The molecular characteristics of canine cortisol-secreting adrenocortical tumours suggest that they will be useful for the study of angiogenesis, the cAMP/protein kinase A pathway, and the role of Steroidogenic Factor-1 in adrenal tumourigenesis. Pet dogs with spontaneous cortisol-secreting adrenocortical tumours may also be useful in clinical testing of new drugs and in investigating the molecular background of adrenocortical tumours.

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JO - Molecular and Cellular Endocrinology

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Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine

Abstract

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