Abstract
In the present study we report the effect of corticosterone in the regulation of hippocampal muscarinic acetylcholine receptor immunoreactivity (mAChR-ir) expression in rats. Adrenalectomy (ADX) or a single injection of a mineralocorticoid antagonist RU-28318 (1.0 mg/100 g body weight (b.w.)) in adrenally intact rats 24 h prior to sacrifice revealed an increased mAChR-ir in hippocampal CA1 and CA3 areas. Corticosterone replacement (100 mu g/100 g b.w.) prevented the increase in mAChR-ir of ADX animals. However, glucocorticoid receptor antagonist (RU38486) treatment in adrenally intact rats failed to affect the mAChR immunolabeling, These results point to a modulation of muscarinic receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 41-44 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 268 |
| Issue number | 1 |
| Publication status | Published - 11 Jun 1999 |
Keywords
- muscarinic receptor
- adrenalectomy
- corticosterone
- glucocorticoid antagonist
- mineralocorticoid antagonist
- ANTAGONISTS
- MODULATION
- BLOCKADE
- SYSTEM
- STRESS