Abstract
Equation presented. Full conversion and enantioselectivities up to 83% have been obtained in the conjugate addition reactions of diethyl zinc to Michael acceptors catalyzed by well-defined (chiral) copper(I) aminoarenethiolates. Interesting differences between organozinc or Grignard reagents have been found: for cyclic enones R2Zn reagents afford better results, whereas earlier work showed that RMgX reagents react more selectively with acyclic enones.
| Original language | English |
|---|---|
| Pages (from-to) | 1959-1962 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 12 |
| Publication status | Published - 10 Jun 2004 |
Keywords
- copper complex
- ketone derivative
- reagent
- thiol derivative
- zinc
- addition reaction
- article
- catalysis
- catalyst
- chemical reaction
- conjugate
- enantioselectivity
- Grignard reaction
- Michael addition
- reaction analysis