Conservation of gene order: A fingerprint of proteins that physically interact

Thomas Dandekar; Berend Snel; Martijn Huynen; Peer Bork

doi:10.1016/S0968-0004(98)01274-2

Conservation of gene order: A fingerprint of proteins that physically interact

Thomas Dandekar
, Berend Snel
, Martijn Huynen
, Peer Bork

Sub Bioinformatics

Europ. Molecular Biology Laboratory
Max-Delbruck-Ctr. fuer Molec. Med.

Research output: Contribution to journal › Book/Film/Article review › Academic

Abstract

A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products. Copyright (C) 1998 Elsevier Science Ltd.

Original language	English
Pages (from-to)	324-328
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/S0968-0004(98)01274-2
Publication status	Published - 1 Sept 1998

Keywords

protein
gene cluster
gene order
human
molecular evolution
nonhuman
priority journal
prokaryote
protein interaction
review

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10.1016/S0968-0004(98)01274-2

Cite this

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title = "Conservation of gene order: A fingerprint of proteins that physically interact",

abstract = "A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products. Copyright (C) 1998 Elsevier Science Ltd.",

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AU - Dandekar, Thomas

AU - Snel, Berend

AU - Huynen, Martijn

AU - Bork, Peer

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Y1 - 1998/9/1

N2 - A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products. Copyright (C) 1998 Elsevier Science Ltd.

AB - A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products. Copyright (C) 1998 Elsevier Science Ltd.

KW - protein

KW - gene cluster

KW - gene order

KW - human

KW - molecular evolution

KW - nonhuman

KW - priority journal

KW - prokaryote

KW - protein interaction

KW - review

U2 - 10.1016/S0968-0004(98)01274-2

DO - 10.1016/S0968-0004(98)01274-2

M3 - Book/Film/Article review

SN - 0968-0004

VL - 23

SP - 324

EP - 328

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 9

ER -

Conservation of gene order: A fingerprint of proteins that physically interact

Abstract

Keywords

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