Consecutive dynamic resolutions of phosphine oxides

Felix A. Kortmann; Mu Chieh Chang; Edwin Otten; Erik P A Couzijn; Martin Lutz; Adriaan J. Minnaard

doi:10.1039/c3sc52913d

Consecutive dynamic resolutions of phosphine oxides

Felix A. Kortmann
, Mu Chieh Chang
, Edwin Otten
, Erik P A Couzijn^*
, Martin Lutz
, Adriaan J. Minnaard

^*Corresponding author for this work

Utrecht University
Swiss Federal Institute of Technology Zurich
University of Groningen
Laboratorium für Organische Chemie
HCI G 204

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

Original language	English
Pages (from-to)	1322-1327
Number of pages	6
Journal	Chemical Science
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/c3sc52913d
Publication status	Published - 1 Apr 2014

Access to Document

10.1039/c3sc52913d

Cite this

@article{55526aa80d574fefb838e84b158a9705,

title = "Consecutive dynamic resolutions of phosphine oxides",

abstract = "A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.",

author = "Kortmann, \{Felix A.\} and Chang, \{Mu Chieh\} and Edwin Otten and Couzijn, \{Erik P A\} and Martin Lutz and Minnaard, \{Adriaan J.\}",

year = "2014",

month = apr,

day = "1",

doi = "10.1039/c3sc52913d",

language = "English",

volume = "5",

pages = "1322--1327",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Consecutive dynamic resolutions of phosphine oxides

AU - Kortmann, Felix A.

AU - Chang, Mu Chieh

AU - Otten, Edwin

AU - Couzijn, Erik P A

AU - Lutz, Martin

AU - Minnaard, Adriaan J.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

AB - A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

UR - https://www.scopus.com/pages/publications/84897677607

U2 - 10.1039/c3sc52913d

DO - 10.1039/c3sc52913d

M3 - Article

AN - SCOPUS:84897677607

SN - 2041-6520

VL - 5

SP - 1322

EP - 1327

JO - Chemical Science

JF - Chemical Science

IS - 4

ER -

Consecutive dynamic resolutions of phosphine oxides

Abstract

Access to Document

Other files and links

Embargoed Document

Fingerprint

Cite this