Consecutive dynamic resolutions of phosphine oxides

Felix A. Kortmann; Mu Chieh Chang; Edwin Otten; Erik P A Couzijn; Martin Lutz; Adriaan J. Minnaard

doi:10.1039/c3sc52913d

Consecutive dynamic resolutions of phosphine oxides

Felix A. Kortmann, Mu Chieh Chang, Edwin Otten, Erik P A Couzijn^*, Martin Lutz, Adriaan J. Minnaard

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

Original language	English
Pages (from-to)	1322-1327
Number of pages	6
Journal	Chemical Science
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/c3sc52913d
Publication status	Published - 1 Apr 2014

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title = "Consecutive dynamic resolutions of phosphine oxides",

abstract = "A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.",

author = "Kortmann, {Felix A.} and Chang, {Mu Chieh} and Edwin Otten and Couzijn, {Erik P A} and Martin Lutz and Minnaard, {Adriaan J.}",

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AU - Kortmann, Felix A.

AU - Chang, Mu Chieh

AU - Otten, Edwin

AU - Couzijn, Erik P A

AU - Lutz, Martin

AU - Minnaard, Adriaan J.

PY - 2014/4/1

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AB - A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

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U2 - 10.1039/c3sc52913d

DO - 10.1039/c3sc52913d

M3 - Article

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SN - 2041-6520

VL - 5

SP - 1322

EP - 1327

JO - Chemical Science

JF - Chemical Science

IS - 4

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Consecutive dynamic resolutions of phosphine oxides

Abstract

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