Consecutive dynamic resolutions of phosphine oxides

Felix A. Kortmann, Mu Chieh Chang, Edwin Otten, Erik P A Couzijn*, Martin Lutz, Adriaan J. Minnaard

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

Original languageEnglish
Pages (from-to)1322-1327
Number of pages6
JournalChemical Science
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Apr 2014

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