Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles

Agnes T. Reiner; Kenneth W. Witwer; Bas W.M. Van Balkom; Joel De Beer; Chaya Brodie; Randolph L. Corteling; Susanne Gabrielsson; Mario Gimona; Ahmed G. Ibrahim; Dominique De Kleijn; Charles P. Lai; Jan Lo Tvall; Hernando A. Del Portillo; Ilona G. Reischl; Milad Riazifar; Carlos Salomon; Hidetoshi Tahara; Wei Seong Toh; Marca H.M. Wauben; Vicky K. Yang; Yijun Yang; Ronne Wee Yeh Yeo; Hang Yin; Bernd Giebel; Eva Rohde; Sai Kiang Lim

doi:10.1002/sctm.17-0055

Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles

Agnes T. Reiner
, Kenneth W. Witwer
, Bas W.M. Van Balkom
, Joel De Beer
, Chaya Brodie
, Randolph L. Corteling
, Susanne Gabrielsson
, Mario Gimona
, Ahmed G. Ibrahim
, Dominique De Kleijn
, Charles P. Lai
, Jan Lo Tvall
, Hernando A. Del Portillo
, Ilona G. Reischl
, Milad Riazifar
, Carlos Salomon
, Hidetoshi Tahara
, Wei Seong Toh
, Marca H.M. Wauben
, Vicky K. Yang

Yijun Yang, Ronne Wee Yeh Yeo, Hang Yin, Bernd Giebel, Eva Rohde^*, Sai Kiang Lim

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.

Original language	English
Pages (from-to)	1730-1739
Number of pages	10
Journal	Stem cells translational medicine
Volume	6
Issue number	8
DOIs	https://doi.org/10.1002/sctm.17-0055
Publication status	Published - 1 Aug 2017

Keywords

Cellular therapy
Clinical translation
Clinical trials
Exosomes
Extracellular vesicles
Microvesicles
Stem cells
Therapeutics

Access to Document

10.1002/sctm.17-0055Licence: CC BY-NC-ND

stcltm_6_8_1730Final published version, 508 KBLicence: CC BY-NC-ND

Cite this

Reiner, A. T., Witwer, K. W., Van Balkom, B. W. M., De Beer, J., Brodie, C., Corteling, R. L., Gabrielsson, S., Gimona, M., Ibrahim, A. G., De Kleijn, D., Lai, C. P., Tvall, J. L., Del Portillo, H. A., Reischl, I. G., Riazifar, M., Salomon, C., Tahara, H., Toh, W. S., Wauben, M. H. M., ... Lim, S. K. (2017). Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles. Stem cells translational medicine, 6(8), 1730-1739. https://doi.org/10.1002/sctm.17-0055

@article{b8413499e52f45f382c78749f3df9a1a,

title = "Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles",

abstract = "Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.",

keywords = "Cellular therapy, Clinical translation, Clinical trials, Exosomes, Extracellular vesicles, Microvesicles, Stem cells, Therapeutics",

author = "Reiner, \{Agnes T.\} and Witwer, \{Kenneth W.\} and \{Van Balkom\}, \{Bas W.M.\} and \{De Beer\}, Joel and Chaya Brodie and Corteling, \{Randolph L.\} and Susanne Gabrielsson and Mario Gimona and Ibrahim, \{Ahmed G.\} and \{De Kleijn\}, Dominique and Lai, \{Charles P.\} and Tvall, \{Jan Lo\} and \{Del Portillo\}, \{Hernando A.\} and Reischl, \{Ilona G.\} and Milad Riazifar and Carlos Salomon and Hidetoshi Tahara and Toh, \{Wei Seong\} and Wauben, \{Marca H.M.\} and Yang, \{Vicky K.\} and Yijun Yang and Yeo, \{Ronne Wee Yeh\} and Hang Yin and Bernd Giebel and Eva Rohde and Lim, \{Sai Kiang\}",

year = "2017",

month = aug,

day = "1",

doi = "10.1002/sctm.17-0055",

language = "English",

volume = "6",

pages = "1730--1739",

journal = "Stem cells translational medicine",

issn = "2157-6564",

publisher = "Oxford University Press",

number = "8",

}

Reiner, AT, Witwer, KW, Van Balkom, BWM, De Beer, J, Brodie, C, Corteling, RL, Gabrielsson, S, Gimona, M, Ibrahim, AG, De Kleijn, D, Lai, CP, Tvall, JL, Del Portillo, HA, Reischl, IG, Riazifar, M, Salomon, C, Tahara, H, Toh, WS, Wauben, MHM, Yang, VK, Yang, Y, Yeo, RWY, Yin, H, Giebel, B, Rohde, E & Lim, SK 2017, 'Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles', Stem cells translational medicine, vol. 6, no. 8, pp. 1730-1739. https://doi.org/10.1002/sctm.17-0055

TY - JOUR

T1 - Concise review

T2 - Developing best-practice models for the therapeutic use of extracellular vesicles

AU - Reiner, Agnes T.

AU - Witwer, Kenneth W.

AU - Van Balkom, Bas W.M.

AU - De Beer, Joel

AU - Brodie, Chaya

AU - Corteling, Randolph L.

AU - Gabrielsson, Susanne

AU - Gimona, Mario

AU - Ibrahim, Ahmed G.

AU - De Kleijn, Dominique

AU - Lai, Charles P.

AU - Tvall, Jan Lo

AU - Del Portillo, Hernando A.

AU - Reischl, Ilona G.

AU - Riazifar, Milad

AU - Salomon, Carlos

AU - Tahara, Hidetoshi

AU - Toh, Wei Seong

AU - Wauben, Marca H.M.

AU - Yang, Vicky K.

AU - Yang, Yijun

AU - Yeo, Ronne Wee Yeh

AU - Yin, Hang

AU - Giebel, Bernd

AU - Rohde, Eva

AU - Lim, Sai Kiang

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.

AB - Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.

KW - Cellular therapy

KW - Clinical translation

KW - Clinical trials

KW - Exosomes

KW - Extracellular vesicles

KW - Microvesicles

KW - Stem cells

KW - Therapeutics

UR - https://www.scopus.com/pages/publications/85024903364

U2 - 10.1002/sctm.17-0055

DO - 10.1002/sctm.17-0055

M3 - Review article

AN - SCOPUS:85024903364

SN - 2157-6564

VL - 6

SP - 1730

EP - 1739

JO - Stem cells translational medicine

JF - Stem cells translational medicine

IS - 8

ER -

Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this