Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Jiaxing Gong; Carl C.L. Schuurmans; Anne Metje van Genderen; Xia Cao; Wanlu Li; Feng Cheng; Jacqueline Jialu He; Arturo López; Valentin Huerta; Jennifer Manríquez; Ruiquan Li; Hongbin Li; Clément Delavaux; Shikha Sebastian; Pamela E. Capendale; Huiming Wang; Jingwei Xie; Mengfei Yu; Rosalinde Masereeuw; Tina Vermonden; Yu Shrike Zhang

doi:10.1038/s41467-020-14997-4

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Jiaxing Gong, Carl C.L. Schuurmans, Anne Metje van Genderen, Xia Cao, Wanlu Li, Feng Cheng, Jacqueline Jialu He, Arturo López, Valentin Huerta, Jennifer Manríquez, Ruiquan Li, Hongbin Li, Clément Delavaux, Shikha Sebastian, Pamela E. Capendale, Huiming Wang, Jingwei Xie, Mengfei Yu, Rosalinde Masereeuw, Tina VermondenYu Shrike Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

Original language	English
Article number	1267
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-14997-4
Publication status	Published - 1 Dec 2020

Keywords

Bioinspired materials
Polymers
Soft materials

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10.1038/s41467-020-14997-4

ComplexationFinal published version, 4.57 MB

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Gong, J., Schuurmans, C. C. L., Genderen, A. M. V., Cao, X., Li, W., Cheng, F., He, J. J., López, A., Huerta, V., Manríquez, J., Li, R., Li, H., Delavaux, C., Sebastian, S., Capendale, P. E., Wang, H., Xie, J., Yu, M., Masereeuw, R., ... Zhang, Y. S. (2020). Complexation-induced resolution enhancement of 3D-printed hydrogel constructs. Nature Communications, 11(1), Article 1267. https://doi.org/10.1038/s41467-020-14997-4

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title = "Complexation-induced resolution enhancement of 3D-printed hydrogel constructs",

abstract = "Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.",

keywords = "Bioinspired materials, Polymers, Soft materials",

author = "Jiaxing Gong and Schuurmans, {Carl C.L.} and Genderen, {Anne Metje van} and Xia Cao and Wanlu Li and Feng Cheng and He, {Jacqueline Jialu} and Arturo L{\'o}pez and Valentin Huerta and Jennifer Manr{\'i}quez and Ruiquan Li and Hongbin Li and Cl{\'e}ment Delavaux and Shikha Sebastian and Capendale, {Pamela E.} and Huiming Wang and Jingwei Xie and Mengfei Yu and Rosalinde Masereeuw and Tina Vermonden and Zhang, {Yu Shrike}",

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doi = "10.1038/s41467-020-14997-4",

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Gong, J, Schuurmans, CCL, Genderen, AMV, Cao, X, Li, W, Cheng, F, He, JJ, López, A, Huerta, V, Manríquez, J, Li, R, Li, H, Delavaux, C, Sebastian, S, Capendale, PE, Wang, H, Xie, J, Yu, M, Masereeuw, R , Vermonden, T & Zhang, YS 2020, 'Complexation-induced resolution enhancement of 3D-printed hydrogel constructs', Nature Communications, vol. 11, no. 1, 1267. https://doi.org/10.1038/s41467-020-14997-4

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AU - Cheng, Feng

AU - He, Jacqueline Jialu

AU - López, Arturo

AU - Huerta, Valentin

AU - Manríquez, Jennifer

AU - Li, Ruiquan

AU - Li, Hongbin

AU - Delavaux, Clément

AU - Sebastian, Shikha

AU - Capendale, Pamela E.

AU - Wang, Huiming

AU - Xie, Jingwei

AU - Yu, Mengfei

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AU - Vermonden, Tina

AU - Zhang, Yu Shrike

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AB - Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

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Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

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