TY - JOUR
T1 - COMPLEMENT DEFICIENCIES IN PATIENTS OVER TEN YEARS OLD WITH MENINGOCOCCAL DISEASE DUE TO UNCOMMON SEROGROUPS
AU - Fijen, Cees A.P.
AU - Hannema, Andre T.
AU - Kuijper, Ed J.
AU - Sjöholm, Anders G.
AU - Van Putten, Jos P.M.
PY - 1989/9/9
Y1 - 1989/9/9
N2 - 46 patients in whom meningococcal disease due to serogroups X, Y, Z, W135, or 29E had developed after the age of 10 years were investigated retrospectively for complement deficiency. Complement deficiency was found in half of the patients: properdin deficiency in 9 patients, C3 deficiency syndromes in 5, and homozygous deficiency of a terminal component (C5, C6, C7, or C8) in 9. Meningococcal infections recurred in 5 of the 9 patients with terminal complement component deficiencies but not in the other complement-deficient patients. The findings show that meningococcal disease due to uncommon serogroups is often associated with complement deficiency.
AB - 46 patients in whom meningococcal disease due to serogroups X, Y, Z, W135, or 29E had developed after the age of 10 years were investigated retrospectively for complement deficiency. Complement deficiency was found in half of the patients: properdin deficiency in 9 patients, C3 deficiency syndromes in 5, and homozygous deficiency of a terminal component (C5, C6, C7, or C8) in 9. Meningococcal infections recurred in 5 of the 9 patients with terminal complement component deficiencies but not in the other complement-deficient patients. The findings show that meningococcal disease due to uncommon serogroups is often associated with complement deficiency.
UR - http://www.scopus.com/inward/record.url?scp=0024446314&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(89)90712-5
DO - 10.1016/S0140-6736(89)90712-5
M3 - Article
C2 - 2570284
AN - SCOPUS:0024446314
SN - 0140-6736
VL - 334
SP - 585
EP - 588
JO - The Lancet
JF - The Lancet
IS - 8663
ER -