Comparison of electrophysiological models for human ventricular cells and tissues

Kirsten H.W.J. Ten Tusscher, Olivier Bernus, Rok Hren, Alexander V. Panfilov

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In this paper we briefly review currently published models for human ventricular cells and tissues. We discuss the Priebe-Beuckelmann (PB) model and the reduced version of this model constructed by Bernus et al. (redPB), the Ten Tusscher-Noble-Noble-Panfilov (TNNP) model and the Iyer-Mazhari-Winslow (IMW) model. We compare several characteristics of these models such as: sources of experimental data the models are based on, action potential morphology, action potential duration (APD) and conduction velocity (CV) restitution and computational efficiency. Finally, we discuss the application of a subset of these models - the redPB and the TNNP model - to study simulated spiral wave dynamics in 2D tissue sheets and in the human ventricles. We discuss the suitability of the different models for particular research questions and their limitations. © 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)326-345
Number of pages20
JournalProgress in Biophysics & Molecular Biology
Volume90
Issue number1-3
DOIs
Publication statusPublished - 2006

Keywords

  • Arrhythmia
  • Electrophysiology
  • Human ventricular cell
  • Mathematical model
  • Re-entry
  • action potential
  • animal
  • biological model
  • comparative study
  • conference paper
  • heart muscle cell
  • heart ventricle
  • human
  • ion transport
  • physiology

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