Abstract
In this paper we briefly review currently published models for human ventricular cells and tissues. We discuss the Priebe-Beuckelmann (PB) model and the reduced version of this model constructed by Bernus et al. (redPB), the Ten Tusscher-Noble-Noble-Panfilov (TNNP) model and the Iyer-Mazhari-Winslow (IMW) model. We compare several characteristics of these models such as: sources of experimental data the models are based on, action potential morphology, action potential duration (APD) and conduction velocity (CV) restitution and computational efficiency. Finally, we discuss the application of a subset of these models - the redPB and the TNNP model - to study simulated spiral wave dynamics in 2D tissue sheets and in the human ventricles. We discuss the suitability of the different models for particular research questions and their limitations. © 2005 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 326-345 |
Number of pages | 20 |
Journal | Progress in Biophysics & Molecular Biology |
Volume | 90 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - 2006 |
Keywords
- Arrhythmia
- Electrophysiology
- Human ventricular cell
- Mathematical model
- Re-entry
- action potential
- animal
- biological model
- comparative study
- conference paper
- heart muscle cell
- heart ventricle
- human
- ion transport
- physiology