Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species

Mathias Devreese, Siska M Croubels, Siegrid De Baere, Ronette Gehring, Gunther Antonissen

    Research output: Contribution to journalArticleAcademicpeer-review


    Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly ( Tmax = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens ( Tmax = 1.43-4.63 h). The absolute oral bioavailability was complete in these bird species (88.0-109.6%). Ducks have a significantly higher volume of distribution ( Vd) and turkeys a lower Vd compared to chickens and layers (broiler chickens, 0.27 ± 0.12 L/kg; layers, 0.23 ± 0.08 L/kg; turkeys, 0.18 ± 0.04 L/kg; ducks, 0.76 ± 0.44 L/kg). This difference in Vd can be attributed to the species-dependent differences in plasma protein binding of OTA, namely ranging between 82.2 and 88.9% in ducks and between 96.5 and 98.8% in turkeys. No significant gender differences were found in toxicokinetics or plasma protein binding.

    Original languageEnglish
    Pages (from-to)2129-2135
    Number of pages7
    JournalJournal of Agricultural and Food Chemistry
    Issue number9
    Publication statusPublished - 2018


    • ochratoxin A
    • toxicokinetics
    • plasma protein binding
    • turkey
    • broiler chicken
    • layer
    • duck
    • birds
    • Toxicokinetics
    • Turkeys


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