Comparative genetics of the major histocompatibility complex in humans and nonhuman primates

Corrine M.c. Heijmans; Natasja G. Groot; Ronald E. Bontrop

doi:10.1111/iji.12490

Comparative genetics of the major histocompatibility complex in humans and nonhuman primates

Corrine M.c. Heijmans, Natasja G. Groot, Ronald E. Bontrop

Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, the Netherlands; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;
Biomedical Primate Research Centre (BPRC)

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The major histocompatibility complex (MHC) is one of the most gene-dense regions of the mammalian genome. Multiple genes within the human MHC (HLA) show extensive polymorphism, and currently, more than 26,000 alleles divided over 39 different genes are known. Nonhuman primate (NHP) species are grouped into great and lesser apes and Old and New World monkeys, and their MHC is studied mostly because of their important role as animal models in preclinical research or in connection with conservation biology purposes. The evolutionary equivalents of many of the HLA genes are present in NHP species, and these genes may also show abundant levels of polymorphism. This review is intended to provide a comprehensive comparison relating to the organization and polymorphism of human and NHP MHC regions.

Original language	English
Pages (from-to)	243-260
Number of pages	18
Journal	International Journal of Immunogenetics
Volume	47
Issue number	3
DOIs	https://doi.org/10.1111/iji.12490
Publication status	Published - Jun 2020

Keywords

genetics
histocompatibility
immunology
molecular biology
nonhuman
polymorphism

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10.1111/iji.12490

iji.12490Final published version, 2.49 MBLicence: Taverne

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abstract = "The major histocompatibility complex (MHC) is one of the most gene-dense regions of the mammalian genome. Multiple genes within the human MHC (HLA) show extensive polymorphism, and currently, more than 26,000 alleles divided over 39 different genes are known. Nonhuman primate (NHP) species are grouped into great and lesser apes and Old and New World monkeys, and their MHC is studied mostly because of their important role as animal models in preclinical research or in connection with conservation biology purposes. The evolutionary equivalents of many of the HLA genes are present in NHP species, and these genes may also show abundant levels of polymorphism. This review is intended to provide a comprehensive comparison relating to the organization and polymorphism of human and NHP MHC regions.",

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AU - Groot, Natasja G.

AU - Bontrop, Ronald E.

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AB - The major histocompatibility complex (MHC) is one of the most gene-dense regions of the mammalian genome. Multiple genes within the human MHC (HLA) show extensive polymorphism, and currently, more than 26,000 alleles divided over 39 different genes are known. Nonhuman primate (NHP) species are grouped into great and lesser apes and Old and New World monkeys, and their MHC is studied mostly because of their important role as animal models in preclinical research or in connection with conservation biology purposes. The evolutionary equivalents of many of the HLA genes are present in NHP species, and these genes may also show abundant levels of polymorphism. This review is intended to provide a comprehensive comparison relating to the organization and polymorphism of human and NHP MHC regions.

KW - genetics

KW - histocompatibility

KW - immunology

KW - molecular biology

KW - nonhuman

KW - polymorphism

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DO - 10.1111/iji.12490

M3 - Article

SN - 1744-3121

VL - 47

SP - 243

EP - 260

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 3

ER -

Comparative genetics of the major histocompatibility complex in humans and nonhuman primates

Abstract

Keywords

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