Comparative assessment of large-scale data sets of protein-protein interactions

Christian Von Mering; Roland Krause; Berend Snel; Michael Cornell; Stephen G. Oliver; Stanley Fields; Peer Bork

Comparative assessment of large-scale data sets of protein-protein interactions

Christian Von Mering, Roland Krause, Berend Snel, Michael Cornell, Stephen G. Oliver, Stanley Fields, Peer Bork

Sub Bioinformatics

European Molec. Biology Laboratory

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Comprehensive protein-protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

Original language	English
Pages (from-to)	399-403
Number of pages	5
Journal	Nature
Volume	417
Issue number	6887
Publication status	Published - 23 May 2002

Keywords

article
cell function
gene expression
genome
intermethod comparison
mass spectrometry
priority journal
protein protein interaction
yeast

Cite this

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title = "Comparative assessment of large-scale data sets of protein-protein interactions",

abstract = "Comprehensive protein-protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.",

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AU - Von Mering, Christian

AU - Krause, Roland

AU - Snel, Berend

AU - Cornell, Michael

AU - Oliver, Stephen G.

AU - Fields, Stanley

AU - Bork, Peer

PY - 2002/5/23

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N2 - Comprehensive protein-protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

AB - Comprehensive protein-protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

KW - article

KW - cell function

KW - gene expression

KW - genome

KW - intermethod comparison

KW - mass spectrometry

KW - priority journal

KW - protein protein interaction

KW - yeast

M3 - Article

SN - 0028-0836

VL - 417

SP - 399

EP - 403

JO - Nature

JF - Nature

IS - 6887

ER -

Comparative assessment of large-scale data sets of protein-protein interactions

Abstract

Keywords

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